• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Ocular responses in healthy subjects to topical bunazosin 0.3%--an alpha 1-adrenoceptor antagonist.健康受试者对局部使用0.3%布那唑嗪（一种α1肾上腺素能受体拮抗剂）的眼部反应。
Br J Ophthalmol. 1991 Jul;75(7):411-3. doi: 10.1136/bjo.75.7.411.
2
Selective suppression by bunazosin of alpha-adrenergic agonist evoked elevation of intraocular pressure in sympathectomized rabbit eyes.
Invest Ophthalmol Vis Sci. 1993 Apr;34(5):1761-6.
3
[Ocular hypotensive effects of topically applied bunazosin, an alpha 1-adrenoceptor blocker, in rabbits and cats].[局部应用α1肾上腺素能受体阻滞剂布那唑嗪对兔和猫的降眼压作用]
Nippon Ganka Gakkai Zasshi. 1991 Aug;95(8):746-51.
4
Effect of bunazosin hydrochloride on intraocular pressure and aqueous humor dynamics in normotensive human eyes.盐酸布那唑嗪对正常血压人眼眼压及房水动力学的影响。
Arch Ophthalmol. 1991 Nov;109(11):1569-74. doi: 10.1001/archopht.1991.01080110105046.
5
Bunazosin reduces intraocular pressure in rabbits by increasing uveoscleral outflow.布那唑嗪通过增加葡萄膜巩膜外流来降低兔眼压。
J Ocul Pharmacol Ther. 1998 Jun;14(3):217-28. doi: 10.1089/jop.1998.14.217.
6
[The effect of bunazosin hydrochloride on intraocular pressure and aqueous humor dynamics in human].
Nippon Ganka Gakkai Zasshi. 1991 Mar;95(3):273-8.
7
Comparative study on the combined effects of bunazosin and nipradilol or timolol on intraocular pressure in normotensive rabbits.布那唑嗪与尼可地尔或噻吗洛尔联合应用对正常血压家兔眼压影响的比较研究
Jpn J Ophthalmol. 2005 Nov-Dec;49(6):523-526. doi: 10.1007/s10384-004-0232-2.
8
[Effects of long-term application of bunazosin hydrochloride eye drops on the aqueous flow rate and blood-aqueous barrier permiability in rabbit eyes].
Nippon Ganka Gakkai Zasshi. 1994 Jun;98(6):540-4.
9
[Changes in intraocular pressure and aqueous humor dynamics of normal human eyes after topical application of bunazosin hydrochloride].[盐酸布那唑嗪局部应用后正常人眼眼压及房水动力学的变化]
Nippon Ganka Gakkai Zasshi. 1990 Aug;94(8):762-8.
10
[Effects of topically applied bunazosin hydrochloride on choroidal capillary blood flow and intraocular pressure of rabbit eye].
Nippon Ganka Gakkai Zasshi. 1991 May;95(5):449-54.

引用本文的文献

1
Effects of antiglaucoma drugs on blood flow of optic nerve heads and related structures.抗青光眼药物对视神经头和相关结构血流的影响。
Jpn J Ophthalmol. 2013 Mar;57(2):133-49. doi: 10.1007/s10384-012-0220-x. Epub 2013 Jan 16.

本文引用的文献

1
The effects of topical prazosin on normal and elevated intraocular pressure and blood pressure in rabbits.局部应用哌唑嗪对兔正常眼压和升高眼压及血压的影响。
Eur J Pharmacol. 1980 Jun 27;64(4):361-3. doi: 10.1016/0014-2999(80)90245-9.
2
Effects of alpha 1 and alpha 2 activation of adrenergic receptors on aqueous humor dynamics.
Life Sci. 1983 Apr 11;32(15):1699-704. doi: 10.1016/0024-3205(83)90831-7.
3
Adrenergic alpha 1 and alpha 2 binding sites are present in bovine retinal blood vessels.肾上腺素能α1和α2结合位点存在于牛视网膜血管中。
Invest Ophthalmol Vis Sci. 1987 Nov;28(11):1741-6.
4
Contemporary antihypertensive therapy.当代抗高血压治疗。
Surv Ophthalmol. 1987 Nov-Dec;32(3):178-88. doi: 10.1016/0039-6257(87)90093-2.
5
The Lang lecture 1986. The enigma of primary open-angle glaucoma.
Trans Ophthalmol Soc U K (1962). 1986;105 ( Pt 6):618-33.
6
Alpha-adrenergic antagonists: correlation of the effect on intraocular pressure and on alpha 2-adrenergic receptor binding specificity in the rabbit eye.α-肾上腺素能拮抗剂：兔眼内眼压作用与α₂-肾上腺素能受体结合特异性的相关性
Exp Eye Res. 1985 Apr;40(4):591-9. doi: 10.1016/0014-4835(85)90081-8.
7
Vasoconstrictive effect of topical timolol on human retinal arteries.局部用噻吗洛尔对人视网膜动脉的血管收缩作用。
Graefes Arch Clin Exp Ophthalmol. 1989;227(6):526-30. doi: 10.1007/BF02169445.
8
Review of alpha adrenoceptor function in the eye.眼部α肾上腺素能受体功能综述。
Eye (Lond). 1989;3 ( Pt 4):472-6. doi: 10.1038/eye.1989.71.
9
Postural studies in pulsatile ocular blood flow: II. Chronic open angle glaucoma.搏动性眼血流的姿势研究：II. 慢性开角型青光眼
Br J Ophthalmol. 1991 Feb;75(2):71-5. doi: 10.1136/bjo.75.2.71.

健康受试者对局部使用0.3%布那唑嗪（一种α1肾上腺素能受体拮抗剂）的眼部反应。

Ocular responses in healthy subjects to topical bunazosin 0.3%--an alpha 1-adrenoceptor antagonist.

作者信息

Trew D R, Wright L A, Smith S E

机构信息

Division of Pharmacological Sciences and Toxicology, United Medical School, London.

出版信息

Br J Ophthalmol. 1991 Jul;75(7):411-3. doi: 10.1136/bjo.75.7.411.

DOI:10.1136/bjo.75.7.411
PMID:1677267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042406/
Abstract

The ocular effects of the alpha-adrenoceptor blocking drug bunazosin, administered as eyedrops, have been measured in a placebo-controlled double-blind single-dose study in 15 healthy volunteers. The drug significantly reduced intraocular pressure over 10 hours, and there was no associated change in pulsatile ocular blood flow. Characteristic effects of alpha-adrenoceptor blockade were observed--miosis, ptosis, and conjunctival hyperaemia. The miosis alone persisted for more than 24 hours in nine out of 15 subjects.

摘要

在一项针对15名健康志愿者的安慰剂对照双盲单剂量研究中，对以眼药水形式给药的α-肾上腺素受体阻断药物布那唑嗪的眼部效应进行了测量。该药物在10小时内显著降低了眼压，且搏动性眼血流量没有相关变化。观察到了α-肾上腺素受体阻断的典型效应——瞳孔缩小、上睑下垂和结膜充血。仅瞳孔缩小在15名受试者中有9名持续超过24小时。