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门静脉高压患者结肠手术后慢性造口静脉曲张出血:β受体阻滞剂的疗效?

Chronic stomal variceal bleeding after colonic surgery in patients with portal hypertension: efficacy of beta-blocking agents?

作者信息

Noubibou Myrène, Douala Hortense C, Druez Patrick M, Kartheuser Alex H, Detry Roger J, Geubel André P

机构信息

Departments of Gastroenterology and Abdominal Surgery, St Luc University Hospital, Université Catholique de Louvain, 1200 Bruxelles, Belgium.

出版信息

Eur J Gastroenterol Hepatol. 2006 Jul;18(7):807-8. doi: 10.1097/01.meg.0000224480.74298.0a.

Abstract

In patients with portal hypertension, ileostomy or colostomy carries the risk of the development of stomal varices at the site of the mucocutaneous junction of a stoma. Such varices are often the source of difficult-to-treat recurrent or chronic bleeding. In this setting, transjugular intrahepatic portosystemic shunt insertion and embolisation is considered the best therapeutic approach in spite of relatively high mortality and morbidity rates. We report the cases of three consecutive patients with portal hypertension of various causes and chronic stomal variceal bleeding in whom beta-blocking therapy resulted in the drying up of bleeding and the prevention of its recurrence for periods of time ranging between 2 and 42 months.

摘要

在门静脉高压患者中,回肠造口术或结肠造口术有在造口黏膜皮肤交界处发生造口静脉曲张的风险。此类静脉曲张常常是难以治疗的复发性或慢性出血的来源。在这种情况下,尽管经颈静脉肝内门体分流术(TIPS)置入和栓塞的死亡率和发病率相对较高,但仍被认为是最佳治疗方法。我们报告了3例连续的门静脉高压患者,病因各异,均有慢性造口静脉曲张出血,β受体阻滞剂治疗使出血停止,并在2至42个月的时间段内预防了出血复发。

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