Pawłowski Przemysław, Myśliwiec Janusz, Mrugacz Małgorzata, Bakunowicz-Łazarczyk Alina, Górska Maria
Department of Paediatric Ophthalmology, Medical University of Białystok.
Endokrynol Pol. 2006 Mar-Apr;57(2):122-6.
To investigate by means of pattern visual evoked potentials (PVEPs) early neuropathic changes in Graves' ophthalmopathy (GO) patients without any clinical symptoms of optic neuropathy in order to evaluate the prevalence of subclinical optic neuropathy in GO patients and to elucidate whether there is a relationship between PVEP (P100 and N75 latency), intraocular pressure (IOP) and exophthalmometry.
Two groups of patients were examined: 15 patients with GO without clinical signs of dysthyroid optic neuropathy (DON) and 12 healthy controls. The correlations between the N75 and P100 latencies, IOP and Hertel exophthalmometry were investigated.
The mean PVEP N75 and P100 latencies were significantly delayed in the GO uncomplicated with DON in comparison with controls (LP100- 106.2 +/- 4.4 ms vs. 102.4 +/- 2.7 ms, p < 0.01 and LN75- 79.0 +/- 3.7 ms vs. 73.9 +/- 2.8 ms, p < 0.001). In GO patients we documented a positive correlation between the LN75 latency and exophthalmometric readings (R = 0.51; p < 0.01). The value of LP100 and LN75 was above the normal limit in 5/30 eyes (17%) and in 3/30 eyes (10%) respectively.
The assessment of PVEPs (especially the P100 latency) in GO patients without clinical signs of DON is a useful tool for the early diagnosis of optic nerve involvement.
通过图形视觉诱发电位（PVEPs）研究Graves眼病（GO）患者在无任何视神经病变临床症状时的早期神经病变改变，以评估GO患者亚临床视神经病变的患病率，并阐明PVEP（P100和N75潜伏期）、眼压（IOP）与眼球突出度测量之间是否存在关系。
检查两组患者：15例无甲状腺功能障碍性视神经病变（DON）临床体征的GO患者和12例健康对照者。研究N75和P100潜伏期、IOP与Hertel眼球突出度测量之间的相关性。
与对照组相比，未合并DON的GO患者的平均PVEP N75和P100潜伏期显著延迟（LP100 - 106.2±4.4毫秒对102.4±2.7毫秒，p<0.01；LN75 - 79.0±3.7毫秒对73.9±2.8毫秒，p<0.001）。在GO患者中，我们记录到LN75潜伏期与眼球突出度测量值之间呈正相关（R = 0.51；p<0.01）。LP100和LN75的值分别在5/30只眼（17%）和3/30只眼（10%）中高于正常范围。
对无DON临床体征的GO患者进行PVEPs评估（尤其是P100潜伏期）是早期诊断视神经受累的有用工具。
