De Marco R, Ambrosio G, Ferrara G
Università degli Studi di Napoli--Federico II, Facoltà di Medicina e Chirurgia, Istituto di Oftalmologia, Italy.
Doc Ophthalmol. 2000 Sep;101(2):165-77. doi: 10.1023/a:1026557401041.
The present study compares contrast sensitivity functions of patients with uncomplicated Graves' ophthalmopathy, patients with ophthalmopathy and elevated intraocular pressure or suspect glaucoma, and patients with dysthyroid optic neuropathy (DON). Aim of the study was to investigate the clinical potential for the contrast sensitivity functions (CSF) in distinguish between the groups. Contrast sensitivity measurements were obtained from twenty-seven subjects with endocrine ophthalmopathy. Group I included patients with uncomplicated ophthalmopathy (n=20 eyes); group II included patients with ophthalmopathy, intraocular pressure > or = 24 mmHg with and without early visual field defects, and no evidence of apical crowding on coronal computed tomography scan (n=14 eyes); group III included patients with DON (n=12 eyes). Contrast thresholds were determined for stationary and 6.87 Hz phase-alternating gratings at eight spatial frequencies from 0.18 to 15.7 c/deg. Data from each group was compared with data from age-matched normal subjects. Observers with uncomplicated ophthalmopathy had normal CSFs. Eyes affected with DON showed contrast sensitivity disruption at overall intermediate-high spatial frequencies. Eyes with elevated intraocular pressure or suspect glaucoma had pronounced sensitivity loss in the low frequency range (0.18-0.70 c/deg) as compared to eyes with DON. This study shows that CSF detects visual function abnormalities noninvasively in patients with complicated Graves' ophthalmopathy. Results also indicate that the clinical potential for CSF in distinguish between patients suffering from ophthalmopathy complicated by ocular hypertension or suspect glaucoma and patients with DON improves when a temporal modulation of 6.87 Hz and gratings of low spatial frequency (< 1 c/deg) are used.
本研究比较了单纯性格雷夫斯眼病患者、患有眼病且眼压升高或疑似青光眼患者以及甲状腺功能障碍性视神经病变（DON）患者的对比敏感度函数。本研究的目的是探讨对比敏感度函数（CSF）在区分这些组别的临床潜力。从27名患有内分泌性眼病的受试者中获得了对比敏感度测量值。第一组包括单纯性眼病患者（n = 20只眼）；第二组包括患有眼病、眼压≥24 mmHg且有或无早期视野缺损且冠状位计算机断层扫描未显示眶尖拥挤迹象的患者（n = 14只眼）；第三组包括患有DON的患者（n = 12只眼）。在从0.18至15.7 c/deg的八个空间频率下，测定了静态和6.87 Hz相位交替光栅的对比阈值。将每组的数据与年龄匹配的正常受试者的数据进行比较。患有单纯性眼病的观察者的CSF正常。患有DON的眼睛在整个中高空间频率下显示对比敏感度破坏。与患有DON的眼睛相比，眼压升高或疑似青光眼的眼睛在低频范围（0.18 - 0.70 c/deg）有明显的敏感度损失。本研究表明，CSF可无创检测复杂性格雷夫斯眼病患者的视觉功能异常。结果还表明，当使用6.87 Hz的时间调制和低空间频率（<1 c/deg）的光栅时，CSF在区分患有眼部高血压或疑似青光眼并发症的眼病患者与患有DON的患者方面的临床潜力有所提高。
