脱氧核糖核酸酶I诱导染色体畸变
Induction of chromosomal aberrations by DNase I.
作者信息
Folle G A, Johannes C, Obe G
机构信息
Division of Human Cytogenetics and Quantitative Microscopy, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
出版信息
Int J Radiat Biol. 1991 Jun;59(6):1371-8. doi: 10.1080/09553009114551231.
Chinese hamster ovary (CHO) cells were treated with bovine pancreatic DNase I using the method of electroporation. The enzyme induced chromosomal aberrations in a S-phase independent manner. The frequencies of polycentric chromosomes induced in the G1 phase of the cell cycle are positively correlated with the dose of DNase I. The distributions of DNase I-induced polycentric chromosomes were overdispersed.
采用电穿孔法用牛胰腺DNA酶I处理中国仓鼠卵巢（CHO）细胞。该酶以不依赖S期的方式诱导染色体畸变。在细胞周期G1期诱导的多着丝粒染色体频率与DNA酶I的剂量呈正相关。DNA酶I诱导的多着丝粒染色体分布呈过度分散状态。
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