Reddy Leleti Rajender, Reddy B V Subba, Corey E J
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Org Lett. 2006 Jun 22;8(13):2819-21. doi: 10.1021/ol060952v.
[reaction: see text] A useful process for the position-selective remote bromination of N-trifluoroacetyl-alpha-amino esters is illustrated for the isoleucine case. The 5-bromoisoleucine derivative shown above can be used for the synthesis of many modified amino acids, as described herein.
[反应：见正文] 以异亮氨酸为例，说明了一种用于N-三氟乙酰基-α-氨基酸酯的位置选择性远程溴化的有用方法。如上所示的5-溴异亮氨酸衍生物可用于合成本文所述的许多修饰氨基酸。
