Sachdev P S
Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, NSW.
Med J Aust. 1991 Jul 15;155(2):75-9.
To study the use of psychoactive drugs for the treatment of long-stay developmentally disabled individuals in an institution in New South Wales.
Three wards dedicated to the long-term care of developmentally disabled individuals situated on the premises of a large psychiatric hospital.
All residents (n = 53) of these wards in August 1989.
All subjects were examined by the author. Charts and medication records were extensively reviewed. Mental retardation was classified by DSM-III-R criteria. Categorisation of problem behaviour was done with the assistance of nurses, who also supplied information on behavioural problems and functional level and completed checklists of self-injurious and stereotypic behaviour. A standardised neurological examination was performed and scales for abnormal involuntary movements completed.
The most commonly used drugs were the neuroleptics, with 60.4% of subjects currently receiving one or more neuroleptic drug at relatively large doses. The use of these drugs was not associated with current or past psychiatric illness, but was more closely related with the severity of problem behaviour. Thirty-four per cent of the subjects receiving neuroleptics had dyskinetic movements suggestive of tardive dyskinesia, and 30% had mild tremor. Antidepressant, anxiolytic and sedative drugs were used less commonly. The management of epilepsy was considered to be suboptimal.
Even though studies over the last two decades have consistently highlighted the problem of overmedication of intellectually handicapped individuals in institutions, the problem does not seem to have been redressed in at least some institutions.
研究在新南威尔士州一家机构中使用精神活性药物治疗长期住院的发育障碍个体。
在一家大型精神病医院内设有三个专门用于长期照料发育障碍个体的病房。
1989年8月这些病房的所有住院患者(n = 53)。
所有研究对象均由作者进行检查。对病历和用药记录进行了广泛审查。根据《精神疾病诊断与统计手册》第三版修订版(DSM-III-R)标准对智力发育迟缓进行分类。在护士的协助下对问题行为进行分类,护士还提供了有关行为问题、功能水平的信息,并完成了自我伤害和刻板行为清单。进行了标准化的神经系统检查并完成了异常不自主运动量表。
最常用的药物是抗精神病药,60.4%的研究对象目前正在接受一种或多种大剂量的抗精神病药物治疗。这些药物的使用与当前或过去的精神疾病无关,但与问题行为的严重程度关系更为密切。接受抗精神病药物治疗的研究对象中有34%出现了提示迟发性运动障碍的运动障碍,30%有轻度震颤。抗抑郁药、抗焦虑药和镇静药的使用较少。癫痫的治疗被认为不够理想。
尽管过去二十年的研究一直强调机构中智障人士用药过量的问题,但至少在一些机构中,这个问题似乎并未得到解决。