Wieles B, Pool J, Wilke M, Weber M, Kolb H-J, Bontrop R E, Goulmy E
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
Tissue Antigens. 2006 Jul;68(1):62-5. doi: 10.1111/j.1399-0039.2006.00603.x.
The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1(H) allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1(H) allele is present in non-human primate species and dogs. Interestingly, both the HA-1(H) T-cell epitope and its non-immunogenic counterpart HA-1(R) are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.
多态性次要组织相容性抗原HA-1可诱导强烈的T细胞同种异体反应性，对人类白细胞抗原匹配的干细胞移植（SCT）后患者的移植物抗肿瘤活性和移植物抗宿主病的发展具有重要影响。鉴于可能进行转化性动物研究，我们分析了四个哺乳动物物种中二等位基因HA-1位点的进化保守性。我们的结果表明，啮齿动物不编码HA-1(H)等位基因，在HA-1基因的这个位置也没有多态性。相反，HA-1(H)等位基因存在于非人类灵长类动物和狗中。有趣的是，HA-1(H) T细胞表位及其非免疫原性对应物HA-1(R)都存在于后一类物种中。因此，HA-1等位基因多态性在灵长类动物和狗的进化中是保守的。
