Takashima S, Becker L E
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Neuropediatrics. 1991 May;22(2):97-9. doi: 10.1055/s-2008-1071424.
Catecholaminergic neurons were characterized by reaction with antiserum to tyrosine hydroxylase, by shape and location and by dendritic ramifications. In this population of cells in the ventrolateral medulla (VLM), the dendritic spines of fusiform and triangular neurons increased with gestational age and rapidly diminished after birth. However, in SIDS, the spines persisted notably in neurons in the VLM but also in the reticular formation and vagal nuclei. These findings suggest a delay in neuronal maturation and may be related to developmental disorders of respiratory, circulatory or sleep-wake regulation.
儿茶酚胺能神经元通过与抗酪氨酸羟化酶血清反应、形状和位置以及树突分支来表征。在延髓腹外侧（VLM）的这群细胞中，梭形和三角形神经元的树突棘随着胎龄增加而增加，并在出生后迅速减少。然而，在婴儿猝死综合征（SIDS）中，树突棘在VLM的神经元中显著持续存在，在网状结构和迷走神经核中也存在。这些发现提示神经元成熟延迟，可能与呼吸、循环或睡眠-觉醒调节的发育障碍有关。
