Khan Naveed Ahmed
School of Biological and Chemical Sciences, Birkbeck College, University of London, London, UK.
FEMS Microbiol Rev. 2006 Jul;30(4):564-95. doi: 10.1111/j.1574-6976.2006.00023.x.
Acanthamoeba is an opportunistic protozoan that is widely distributed in the environment and is well recognized to produce serious human infections, including a blinding keratitis and a fatal encephalitis. This review presents our current understanding of the burden of Acanthamoeba infections on human health, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Acanthamoeba that may be targets for therapeutic interventions and/or the development of preventative measures.
棘阿米巴是一种机会性原生动物，广泛分布于环境中，已知会引发严重的人类感染，包括致盲性角膜炎和致命性脑炎。本综述阐述了我们目前对棘阿米巴感染给人类健康造成的负担、其发病机制和病理生理学、与该疾病相关的分子机制，以及棘阿米巴的毒力特征的理解，这些毒力特征可能是治疗干预和/或预防措施开发的靶点。
