周围神经病和运动神经元病中的抗组织转谷氨酰胺酶IgA抗体
Anti-tissue transglutaminase IgA antibodies in peripheral neuropathy and motor neuronopathy.
作者信息
Matà S, Renzi D, Pinto F, Calabrò A
机构信息
Gastroenterology Unit, Department of Neurological Sciences, University of Florence, Florence, Italy.
出版信息
Acta Neurol Scand. 2006 Jul;114(1):54-8. doi: 10.1111/j.1600-0404.2006.00602.x.
OBJECTIVES
The aim of the study was to investigate the occurence of anti-tissue transglutaminase antibodies (tTGA) in peripheral nerve disorders, and to correlate them with neurophysiologic findings and anti-glycolipid antibodies.
MATERIALS AND METHODS
We examined tTGA immunoglobulin-A serum level from 220 patients with polyneuropathy (acute inflammatory: n=90; chronic inflammatory: n=56; non-inflammatory: n=74) and 110 with motor neuron disease (MND).
RESULTS
Seven of the 330 neurologic patients (2.1%, six with polyneuropathy and one with MND) were positive for tTGA. Sixty-one of the 330 neurologic patients (18.4%) had slightly increased tTGA values compared with healthy controls. Increased tTGA values were associated with greater impairment of neurophysiologic findings, but not with the presence of anti-glycolipid antibodies.
CONCLUSIONS
We found a high prevalence of tTGA reactivity in patients with peripheral nerve disorders or MND. However, we were unable to demonstrate an increased risk of celiac disease in these diseases.
目的
本研究旨在调查周围神经疾病中抗组织转谷氨酰胺酶抗体（tTGA）的发生率，并将其与神经生理学检查结果和抗糖脂抗体进行关联分析。
材料与方法
我们检测了220例多发性神经病患者（急性炎症性：n = 90；慢性炎症性：n = 56；非炎症性：n = 74）和110例运动神经元病（MND）患者的血清tTGA免疫球蛋白A水平。
结果
330例神经科患者中有7例（2.1%，6例多发性神经病患者和1例MND患者）tTGA呈阳性。与健康对照相比，330例神经科患者中有61例（18.4%）的tTGA值略有升高。tTGA值升高与神经生理学检查结果的更严重损害相关，但与抗糖脂抗体的存在无关。
结论
我们发现周围神经疾病或MND患者中tTGA反应性的患病率较高。然而，我们无法证明这些疾病中乳糜泻的风险增加。
Zotero 插件