Patel Saawan C, Shreya Devarashetty, Zamora Diana I, Patel Gautami S, Grossmann Idan, Rodriguez Kevin, Soni Mridul, Joshi Pranay K, Sange Ibrahim
Internal Medicine, Pramukhswami Medical College, Karamsad, IND.
Internal Medicine, Gandhi Medical College, Secunderabad, Hyderabad, IND.
Cureus. 2021 Dec 2;13(12):e20112. doi: 10.7759/cureus.20112. eCollection 2021 Dec.
Celiac disease (CD) is a multi-systemic autoimmune condition that causes a hyperinflammatory response when gluten is ingested. There has been a shift in the clinical presentation of CD from a mere malabsorption disorder to an autoimmune condition that affects multiple organ systems, which could increase the rate of hospitalizations and a decreased quality of life. This article has compiled various studies that have explored the neurological manifestations of celiac disease, their epidemiology, possible pathogenic mechanisms, diagnosis, and treatment. The most common neurological conditions include gluten ataxia (GA), gluten neuropathy, gluten encephalopathy, and epilepsy which usually present as sporadic diseases which are difficult to diagnose in the absence of gastrointestinal (GI) symptoms. The treatment for most of these conditions is a gluten-free diet (GFD) regardless of GI involvement.
乳糜泻（CD）是一种多系统自身免疫性疾病，摄入麸质时会引发超炎症反应。CD的临床表现已从单纯的吸收不良性疾病转变为影响多个器官系统的自身免疫性疾病，这可能会增加住院率并降低生活质量。本文汇编了各项研究，这些研究探讨了乳糜泻的神经学表现、其流行病学、可能的致病机制、诊断和治疗。最常见的神经疾病包括麸质共济失调（GA）、麸质神经病、麸质脑病和癫痫，这些疾病通常表现为散发性疾病，在没有胃肠道（GI）症状的情况下难以诊断。无论是否有胃肠道受累，这些疾病大多采用无麸质饮食（GFD）进行治疗。
