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[黑腹果蝇中ssa的一种新等位基因变体及其在调控腿部和触角成虫盘干细胞增殖中的作用]

[A new allele variant of ssa and its participation in regulating the proliferation of the stem elements of the leg and antenna imaginal disks in Drosophila melanogaster].

作者信息

Kuzin B A, Doszhanov K T, Simonova O B, Gerasimova T I, Guliaev D V

出版信息

Ontogenez. 1991 Mar-Apr;22(2):212-6.

PMID:1677464
Abstract

Using a highly mutable FM/w oc system, we have established a new allele of ssa40aSc mutation whose phenotype is identical to ssa40aNs compound described in the literature. The following features are characteristic of the ssa40aSc flies phenotype: (1) the increased number of sex comb teeth, (2) complete fusion of tarsal segments, and (3) the decreased bristle size corresponding to that of ss flies. The first two features are evidence for the impaired stem cell proliferation in the antennal and leg imaginal discs which are determined to form distal structures. This assumption was experimentally confirmed when we transplanted leg imaginal discs from III instar larvae of different age into prepupae. The observed phenomenon is probably due to the defects of the Antp and Pc translation products binding site in the ss locus.

摘要

利用一个高度可变的FM/w oc系统,我们建立了ssa40aSc突变的一个新等位基因,其表型与文献中描述的ssa40aNs复合突变相同。ssa40aSc果蝇表型具有以下特征:(1)性梳齿数量增加;(2)跗节完全融合;(3)刚毛大小减小,与ss果蝇的刚毛大小相当。前两个特征证明触角和腿部成虫盘的干细胞增殖受损,而这些成虫盘被确定会形成远端结构。当我们将不同年龄的三龄幼虫的腿部成虫盘移植到预蛹中时,这一假设得到了实验证实。观察到的现象可能是由于ss基因座中Antp和Pc翻译产物结合位点的缺陷所致。

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