Brockes J P
Ludwig Institute, London, U.K.
Philos Trans R Soc Lond B Biol Sci. 1991 Mar 29;331(1261):287-90. doi: 10.1098/rstb.1991.0018.
Limb regeneration in adult urodele amphibians proceeds by formation of a blastema at the amputation plane. This paper discusses how the blastema forms, and how its positional identity on the proximodistal axis is manifest. Retinoic acid is able to reset axial specification and there is particular interest in determining how it acts. Although limb regeneration is restricted among vertebrates to the urodeles, its mechanism poses fundamental questions in development biology.
成年有尾两栖动物的肢体再生是通过在截肢平面形成芽基来进行的。本文讨论了芽基是如何形成的，以及它在近远轴上的位置身份是如何体现的。视黄酸能够重置轴向特化，确定其作用方式尤其令人感兴趣。尽管肢体再生在脊椎动物中仅限于有尾两栖动物，但它的机制在发育生物学中提出了一些基本问题。
