Zhang En-ping, Liao Dong-hua, Liu Ai-zhen, Wang Xiao-bing, Li Xiao-yang, Zeng Yan-jun, Wang Su-jie
Beijing Tongren Hospital, Affiliate of Capital University of Medical Science, Beijing 100730, PR China.
Clin Biomech (Bristol). 2006 Oct;21(8):864-9. doi: 10.1016/j.clinbiomech.2006.04.005. Epub 2006 Jun 13.
Free skin graft has to be used when the large area skin are burned. The objective of this study is to quantify the influence of free graft and expansion on the skin biomechanical remodeling.
Four white pigs (weighing from 17 kg to 23 kg) were used. Two 180 ml rectangle expanders were aseptically placed beneath the skin on the back of each pig. Four normal skin flaps and four expanded skin flaps were incised from the foreside back of each pig. Two normal skin flaps and two expanded skin flaps were then grafted to rearward back of the pig. Stress-strain relationship, stress relaxation and creep characters in normal skin: N(n=8), expanded skin without graft: E(n=8), normal skin with free graft after three months: NG(n=8) and expanded skin with free graft after three months: EG(n=8) were measured by using Instron material testing machine.
The strains at 3.5 MPa stress (mean (SD)) are 0.4436(0.1760), 0.4851(0.1401), 0.7750(0.1984) and 0.5854(0.0655) respectively in N, E, NG and EG groups. The maximum relaxations (mean (SD)) are 0.6324(0.0169), 0.6279(0.0401), 0.5630(0.0170) and 0.6057(0.0883) in N, E, NG and EG groups, respectively. The maximum creeps (mean (SD)) are 1.0876(0.0086), 1.1037(0.0116), 1.1948(0.0394) and 1.1328(0.0223) in N, E, NG and EG groups.
The biomechanical characteristics of free graft with expanded skin after three months have no significant difference with the normal skin, expansion skin and free graft with normal skin after three months (P>0.05). The free graft and expansion have no significant influence on the skin biomechanical remodeling.
大面积皮肤烧伤时必须使用游离皮片移植。本研究的目的是量化游离移植和皮肤扩张对皮肤生物力学重塑的影响。
使用4只白色猪（体重17千克至23千克）。将两个180毫升的矩形扩张器无菌放置在每只猪背部的皮肤下方。从每只猪的前侧背部切取4个正常皮瓣和4个扩张皮瓣。然后将两个正常皮瓣和两个扩张皮瓣移植到猪的后侧背部。使用英斯特朗材料试验机测量正常皮肤（N，n = 8）、未移植的扩张皮肤（E，n = 8）、三个月后游离移植的正常皮肤（NG，n = 8）和三个月后游离移植的扩张皮肤（EG，n = 8）的应力-应变关系、应力松弛和蠕变特性。
N、E、NG和EG组在3.5兆帕应力下的应变（均值（标准差））分别为0.4436（0.1760）、0.4851（0.1401）、0.7750（0.1984）和0.5854（0.0655）。N、E、NG和EG组的最大松弛度（均值（标准差））分别为0.6324（0.0169）、0.6279（0.0401）、0.5630（0.
