Schneider M S, Borkow J E, Cruz I T, Marangoni R D, Shaffer J, Grove D
Department of Surgery, Conemaugh Valley Memorial Hospital, Johnstown, PA.
Plast Reconstr Surg. 1988 Mar;81(3):398-405. doi: 10.1097/00006534-198803000-00015.
Our purpose in this study was to evaluate the tensile properties of expanded skin. In five guinea pigs, 29-cc ovoid tissue expanders were placed and sequentially expanded every 4 days until maximum volume was achieved. Five control and five expanded skins were harvested. Using an Instron tensile testing apparatus, skins were evaluated for stress-strain, maximum stiffness, and tensile strength, and the results were statistically compared. Centrally located expanded specimens demonstrated significantly weaker stress-strain values: 9.51 in.lb/in3 for expanded versus 30.11 in.lb/in3 for control (p less than 0.001). Maximum stiffness was similarly reduced: 4.56 lb/mm2 for expanded vs. 12.98 lb/mm2 for control (p less than 0.001). This is a 67.4 and 64.9 percent reduction, respectively, for the stress-strain and maximum stiffness. No statistically significant difference was seen in peripherally located expanded specimens relative to the controls: stress-strain expanded, 28.7 in.lb/in3 (p greater than 0.5); maximum stiffness expanded, 12.84 lb/mm2 (p greater than 0.5). Expanded skin demonstrated an average 35 percent reduction in tensile strength. We conclude that the tensile properties of expanded skin are significantly less than unexpanded skin and are a function of the degree of expansion.
本研究的目的是评估扩张皮肤的拉伸性能。在5只豚鼠身上植入29立方厘米的椭圆形组织扩张器，每4天进行一次顺序扩张，直至达到最大体积。采集5块对照皮肤和5块扩张皮肤。使用英斯特朗拉伸试验仪器对皮肤进行应力-应变、最大刚度和拉伸强度评估，并对结果进行统计学比较。位于中央的扩张样本显示出明显较弱的应力-应变值：扩张皮肤为9.51英寸·磅/立方英寸，对照皮肤为30.11英寸·磅/立方英寸（p<0.001）。最大刚度也同样降低：扩张皮肤为4.56磅/平方毫米，对照皮肤为12.98磅/平方毫米（p<0.001）。应力-应变和最大刚度分别降低了67.4%和64.9%。相对于对照，位于周边的扩张样本未观察到统计学上的显著差异：扩张皮肤应力-应变值为28.7英寸·磅/立方英寸（p>0.5）；扩张皮肤最大刚度为12.84磅/平方毫米（p>0.5）。扩张皮肤的拉伸强度平均降低了35%。我们得出结论，扩张皮肤的拉伸性能明显低于未扩张皮肤，并且是扩张程度的函数。
