Su Wei-Chung, Cheng Yung Sung
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA.
Inhal Toxicol. 2006 Sep;18(10):749-60. doi: 10.1080/08958370600748513.
This study consisted of a series of experiments to investigate the factors that might affect the fiber deposition pattern in the human respiratory tract. Carbon fibers with uniform diameter and polydispersed length were chosen as the test material. Two geometry-defined human respiratory tract replicas encompassing the oral cavity, oropharynx, larynx, trachea, and first few bifurcations of the tracheobronchial airways were used in this research. Deposition studies were conducted by delivering aerosolized carbon fibers into the replicas at constant inspiratory flow rates of 15, 43.5, and 60 L/min. The results showed that impaction is the dominant deposition mechanism for both replicas. Most of the fibers with high momentum deposited in the oral airway (oral cavity to larynx), and fibers with low momentum were found to pass through the entire replica easily. When comparing the results between the two replicas, fiber length, inspiratory flow rate, and the geometry of the oral airway were found to be factors that might affect the fiber deposition pattern in the human respiratory tract.
本研究包括一系列实验，以探究可能影响人类呼吸道中纤维沉积模式的因素。选择直径均匀且长度多分散的碳纤维作为测试材料。本研究使用了两个几何形状确定的人类呼吸道模型，涵盖口腔、口咽、喉、气管以及气管支气管气道的前几个分支。通过以15、43.5和60升/分钟的恒定吸气流量将雾化碳纤维输送到模型中进行沉积研究。结果表明，对于两个模型而言，撞击都是主要的沉积机制。大多数具有高动量的纤维沉积在口腔气道（从口腔到喉）中，而发现低动量的纤维很容易穿过整个模型。在比较两个模型的结果时，发现纤维长度、吸气流量和口腔气道的几何形状是可能影响人类呼吸道中纤维沉积模式的因素。
