Safriel Y, Ali M, Hayt M, Ang R
Center for Diagnostic Imaging, Waite Park, MN, USA.
AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1194-7.
To review the safety and efficacy of gadolinium as a contrast agent in spine pain management procedures in patients who are at high risk for a contrast reaction and are therefore unacceptable candidates for the use of standard nonionic contrast.
We reviewed our records over a 4-year period of interlaminar and foraminal epidural steroid injections, nerve blocks, facet injections, intercostal blocks, and diskograms in the lumbar, thoracic, and cervical spine for cases in which patients had allergies that made them unsuitable candidates for standard nonionic contrast and where gadolinium was used to confirm needle tip placement before injection of medication.
Ninety-two patients underwent 127 procedures. A spinal needle was used in all but 7 procedures. All patients were outpatients and all were discharged without complication after 20 to 45 minutes with follow-up instructions. No delayed complications were reported. Gadolinium was visualized by using portable C-arm fluoroscopy in vivo allowing for confirmation of needle tip location. For epidural steroid injection, the gadolinium dose ranged from 1 to 5 mL, nerve blocks from 0.2 to 1 mL per level, facet injections from 0.2 to 0.5 mL per level, intercostal blocks used 0.5 mL, and diskograms from 1.5 to 7.5 mL per level. The highest dose received by 1 patient was an intradiskal 15.83 mL during a 3-level diskogram.
Gadolinium seems to be a safe alternative to standard nonionic contrast in spine pain management procedures in those patients considered to be at high risk for a contrast reaction.
回顾钆作为造影剂在脊柱疼痛治疗手术中的安全性和有效性,这些患者发生造影剂反应的风险较高,因此不适合使用标准非离子型造影剂。
我们回顾了4年期间在腰椎、胸椎和颈椎进行的椎板间和椎间孔硬膜外类固醇注射、神经阻滞、小关节注射、肋间阻滞和椎间盘造影的记录,这些病例中的患者存在过敏反应,使其不适合使用标准非离子型造影剂,并且在注射药物前使用钆来确认针尖位置。
92例患者接受了127次手术。除7次手术外,所有手术均使用了脊柱穿刺针。所有患者均为门诊患者,术后20至45分钟均出院,无并发症,并给予了随访指导。未报告延迟并发症。通过便携式C形臂荧光透视在体内观察到钆,从而确认了针尖位置。对于硬膜外类固醇注射,钆的剂量范围为1至5毫升,神经阻滞每节段为0.2至1毫升,小关节注射每节段为0.2至0.5毫升,肋间阻滞使用0.5毫升,椎间盘造影每节段为1.5至7.5毫升。1例患者在3节段椎间盘造影期间接受的最高剂量为椎间盘内15.83毫升。
对于那些被认为发生造影剂反应风险较高的患者,在脊柱疼痛治疗手术中,钆似乎是标准非离子型造影剂的一种安全替代品。