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本文引用的文献

1
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.牛体内一种限制逆转录病毒感染的细胞质三联基序（TRIM）蛋白的进化
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7454-9. doi: 10.1073/pnas.0600771103. Epub 2006 Apr 28.
2
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor.TRIM5α限制因子对逆转录病毒衣壳的特异性识别与加速脱壳
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5514-9. doi: 10.1073/pnas.0509996103. Epub 2006 Mar 15.
3
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5.逆转录病毒限制因子TRIM5的快速周转与多聚泛素化
Virology. 2006 Jun 5;349(2):300-15. doi: 10.1016/j.virol.2005.12.040. Epub 2006 Feb 10.
4
Retroviral restriction factor TRIM5alpha is a trimer.逆转录病毒限制因子TRIM5α是一种三聚体。
J Virol. 2005 Nov;79(22):14446-50. doi: 10.1128/JVI.79.22.14446-14450.2005.
5
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.负责逆转录病毒限制活性和特异性的人类三重基序5α结构域。
J Virol. 2005 Jul;79(14):8969-78. doi: 10.1128/JVI.79.14.8969-8978.2005.
6
Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.Ro52的环-盒-卷曲螺旋（RBCC）区域中涉及自身抗原表位的结构组织和锌离子依赖性亚结构域相互作用
J Biol Chem. 2005 Sep 30;280(39):33250-61. doi: 10.1074/jbc.M503066200. Epub 2005 Jun 17.
7
Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.干燥综合征中靶向的Ro52蛋白折叠亚结构域的结构、功能及免疫学特征
Mol Immunol. 2006 Feb;43(6):588-98. doi: 10.1016/j.molimm.2005.04.013.
8
The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.RING和B-box 2结构域对猴TRIM5α介导的逆转录病毒限制的贡献。
J Biol Chem. 2005 Jul 22;280(29):26933-40. doi: 10.1074/jbc.M502145200. Epub 2005 May 15.
9
Uncoating of HIV-1 requires cellular activation.HIV-1的脱壳需要细胞激活。
Virology. 2005 Jun 20;337(1):93-101. doi: 10.1016/j.virol.2005.02.028.
10
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.逆转录病毒限制因子TRIM5α的B30.2（SPRY）结构域在灵长类动物中表现出谱系特异性的长度和序列变异。
J Virol. 2005 May;79(10):6111-21. doi: 10.1128/JVI.79.10.6111-6121.2005.

通过异源TRIM结构域对三联基序5α（TRIM5α）的RING、B-box 2和卷曲螺旋结构域进行功能替换。

Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.

作者信息

Li Xing, Li Yuan, Stremlau Matthew, Yuan Wen, Song Byeongwoon, Perron Michel, Sodroski Joseph

机构信息

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street-JFB 824, Boston, MA 02115, USA.

出版信息

J Virol. 2006 Jul;80(13):6198-206. doi: 10.1128/JVI.00283-06.

DOI:10.1128/JVI.00283-06
PMID:16775307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1488960/
Abstract

Tripartite motif 5alpha (TRIM5alpha) restricts some retroviruses, including human immunodeficiency virus type 1 (HIV-1), from infecting the cells of particular species. TRIM5alpha is a member of the TRIM family of proteins, which contain RING, B-box, coiled-coil (CC), and, in some cases, B30.2(SPRY) domains. Here we investigated the abilities of domains from TRIM proteins (TRIM6, TRIM34, and TRIM21) that do not restrict HIV-1 infection to substitute for the domains of rhesus monkey TRIM5alpha (TRIM5alpha(rh)). The RING, B-box 2, and CC domains of the paralogous TRIM6 and TRIM34 proteins functionally replaced the corresponding TRIM5alpha(rh) domains, allowing HIV-1 restriction. By contrast, similar chimeras containing the components of TRIM21, a slightly more distant relative of TRIM5, did not restrict HIV-1 infection. The TRIM21 B-box 2 domain and its flanking linker regions contributed to the functional defectiveness of these chimeras. All of the chimeric proteins formed trimers. All of the chimeras that restricted HIV-1 infection bound the assembled HIV-1 capsid complexes. These results indicate that heterologous RING, B-box 2, and CC domains from related TRIM proteins can functionally substitute for TRIM5alpha(rh) domains.

摘要

三联基序蛋白5α（TRIM5α）可限制包括1型人类免疫缺陷病毒（HIV-1）在内的一些逆转录病毒感染特定物种的细胞。TRIM5α是TRIM蛋白家族的成员，该家族蛋白包含RING、B盒、卷曲螺旋（CC）结构域，在某些情况下还包含B30.2（SPRY）结构域。在此，我们研究了不限制HIV-1感染的TRIM蛋白（TRIM6、TRIM34和TRIM21）的结构域替代恒河猴TRIM5α（TRIM5α(rh)）结构域的能力。同源的TRIM6和TRIM34蛋白的RING、B盒2和CC结构域在功能上替代了相应的TRIM5α(rh)结构域，从而实现对HIV-1的限制。相比之下，包含TRIM5关系稍远的亲属TRIM21成分的类似嵌合体则不能限制HIV-1感染。TRIM21的B盒2结构域及其侧翼连接区导致了这些嵌合体的功能缺陷。所有嵌合蛋白均形成三聚体。所有限制HIV-1感染的嵌合体都能结合组装好的HIV-1衣壳复合物。这些结果表明，来自相关TRIM蛋白的异源RING、B盒2和CC结构域在功能上可替代TRIM5α(rh)结构域。