一种高度受限的T细胞受体主导了HLA - A*2402阳性个体对细小病毒B19感染的CD8 + T细胞反应。
A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals.
作者信息
Kasprowicz V, Isa A, Jeffery K, Broliden K, Tolfvenstam T, Klenerman P, Bowness P
机构信息
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
出版信息
J Virol. 2006 Jul;80(13):6697-701. doi: 10.1128/JVI.02388-05.
Abstract
Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.
摘要
7名急性B19微小病毒感染的HLA-A*2402阳性个体中有6名对病毒表位FYTPLADQF产生了强烈的CD8阳性细胞毒性T细胞（CTL）反应。所有应答者均表现出高度集中的T细胞受体（TCR）使用情况，几乎仅使用BV5.1。BV5.1 TCR主导急性反应，随时间持续存在，并且一名远距离感染个体也使用该TCR。从3名无关个体获得的9个CTL克隆和2个寡克隆系使用了BV5.1、BJ2.1以及一个由9个氨基酸组成的保守TCR CDR3。这个普遍识别的表位可能在长期保护性免疫中很重要，应纳入疫苗设计。
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