Moreno C B, Gutiérrez-Alvarez A M, González-Reyes R E
Grupo de Investigación en Neurociencias (NEUROS), Universidad Colegio Mayor de Nuestra Señora del Rosario, Facultad de Medicina, Bogotá, Colombia.
Rev Neurol. 2006;42(12):754-9.
Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour.
We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance.
Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results.
锌是神经系统正常功能所必需的微量元素。有研究表明，在大脑中，锌稳态的改变可能与癫痫的发生有关，尽管锌的浓度是癫痫发作的原因还是结果尚未确定。另一个研究较少的方面是抗癫痫药物与神经元锌行为之间的关系。
我们对文献进行了系统综述，以评估锌在癫痫中的作用以及锌浓度的抗癫痫作用。检索了1974年1月至2005年7月的MEDLINE、EMBASE、SCISEARCH和LILACS等数据库。纳入所有以英文和西班牙文发表的文章。对每篇文章中的参考文献进行人工检索，以识别电子检索可能遗漏的文章。在获取全文之前，先分析潜在文章的标题和摘要。然而，对于那些含义不明确的文章，之后会进行全面分析以确定其相关性。
癫痫的临床研究结果相互矛盾。事实上，所综述的动物和人体研究均未提供足够的证据来确定有机锌的变化是否与癫痫直接相关。大多数研究结果无统计学意义。
