Petignat P, Bouchardy C, Sauthier P
Division de gynécologie oncologique, CHUM, 1560, rue Sherbrooke Est Montreal (Québec), Canada.
Rev Med Suisse. 2006 May 17;2(66):1308-9, 1311-2.
Cervical cancer screening with Pap cytology has effectively reduced the incidence of morbidity and mortality from invasive cervical cancer. However, Pap cytology has important limitation and is not completely protective. Invasive cervical cancers are still diagnosed and main reasons are an insufficient coverage rate and presence of false-negative results. HPV testing has greater sensitivity than Pap cytology for detecting high-grade lesions and cancer and is clearly one of the most promising new screening tools. It has the potential to improve cervical cancer screening effectiveness. The aim of our study was to discuss the current situation of cervical cancer screening in Switzerland, limitations of Pap cytology as well as the benefice expected with HPV testing and vaccienes.
采用巴氏细胞学进行宫颈癌筛查已有效降低了浸润性宫颈癌的发病率和死亡率。然而,巴氏细胞学存在重要局限性,并非完全具有保护作用。仍有浸润性宫颈癌被诊断出来,主要原因是覆盖率不足和存在假阴性结果。人乳头瘤病毒(HPV)检测在检测高级别病变和癌症方面比巴氏细胞学具有更高的灵敏度,显然是最有前景的新筛查工具之一。它有可能提高宫颈癌筛查的有效性。我们研究的目的是探讨瑞士宫颈癌筛查的现状、巴氏细胞学的局限性以及HPV检测和疫苗预期带来的益处。