Dustin Michael L, Tseng Su-Yi, Varma Rajat, Campi Gabriele
Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA.
Curr Opin Immunol. 2006 Aug;18(4):512-6. doi: 10.1016/j.coi.2006.05.017. Epub 2006 Jun 13.
Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns.
树突状细胞（DCs）是髓系细胞，受其所处环境影响，并会对微生物产物做出反应而成熟。DC的一个关键作用是将这种特定环境信息传递给T细胞，同时通过形成免疫突触来呈递自身和外来的MHC-肽复合物。T细胞与DC的免疫突触结构不同于与B细胞或支持的平面双层形成的典型结构，因为它有多个T细胞受体相互作用焦点，而非一个中央焦点。对模型系统的最新研究为独特的T细胞与DC突触模式的机制及生物学后果提供了见解。
