Sieper Joachim, Rudwaleit Martin, Khan Muhammed Asim, Braun Jürgen
Department of Medicine, Rheumatology, Charitè, University Medicine Berlin, Germany.
Best Pract Res Clin Rheumatol. 2006 Jun;20(3):401-17. doi: 10.1016/j.berh.2006.02.001.
The term 'spondyloarthritides' (SpA) comprises ankylosing spondylitis (AS), reactive arthritis, arthritis/spondylitis with inflammatory bowel disease, and arthritis/spondylitis with psoriasis. The main links between these diseases are an association with HLA-B27 and a similar clinical picture. Patients normally present with chronic low back pain or asymmetrical arthritis, predominantly of the lower limbs, and an overlap of these symptoms often occurs. AS is regarded as the most severe subtype. Recent attention has focused on earlier diagnosis of AS among patients with chronic low back, and this is becoming more important as effective therapies for early treatment have become available. AS is a disease of young people, normally starting in the third decade of life. The incidence and prevalence rates of AS, and of SpA as a whole, are strongly dependent and are directly correlated to the prevalence of HLA-B27 in a given population. Incidence rates of 0.5-8.2/100 000 population and prevalence rates of 0.2-1.2% have been described for AS, and about double these figures have been reported for SpA.
“脊柱关节炎”（SpA）一词包括强直性脊柱炎（AS）、反应性关节炎、与炎症性肠病相关的关节炎/脊柱炎以及与银屑病相关的关节炎/脊柱炎。这些疾病之间的主要联系是与HLA - B27相关以及临床表现相似。患者通常表现为慢性腰背痛或不对称性关节炎，主要累及下肢，且这些症状常常重叠出现。AS被视为最严重的亚型。近期的关注焦点在于慢性腰背痛患者中AS的早期诊断，随着早期治疗的有效疗法问世，这一点变得愈发重要。AS是一种多见于年轻人的疾病，通常始于30岁左右。AS以及整个SpA的发病率和患病率在很大程度上相互依存，并且与特定人群中HLA - B27的患病率直接相关。AS的发病率为每10万人中有0.5 - 8.2例，患病率为0.2 - 1.2%，而SpA的报告数据约为这些数字的两倍。
