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Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population.韩国人群中酒精中毒与5号染色体q33 - 34上GABAA受体基因的基因多态性之间的关联。
J Korean Med Sci. 2006 Jun;21(3):533-8. doi: 10.3346/jkms.2006.21.3.533.
2
Association analysis of sequence variants of GABA(A) alpha6, beta2, and gamma2 gene cluster and alcohol dependence.γ-氨基丁酸A受体α6、β2和γ2基因簇序列变异与酒精依赖的关联分析
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3
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本文引用的文献

1
No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample.在酒精中毒遗传学合作研究样本中，5号染色体上的GABAA受体基因与酒精中毒无关联。
Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):24-8. doi: 10.1002/ajmg.b.30058.
2
Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster.基于单倍型将酒精依赖基因定位到5q34γ-氨基丁酸A型基因簇。
Arch Gen Psychiatry. 2005 Jan;62(1):47-55. doi: 10.1001/archpsyc.62.1.47.
3
An inventory for measuring depression.一份用于测量抑郁的量表。
Arch Gen Psychiatry. 1961 Jun;4:561-71. doi: 10.1001/archpsyc.1961.01710120031004.
4
Candidate genes for alcohol dependence: a review of genetic evidence from human studies.酒精依赖的候选基因：来自人类研究的遗传证据综述
Alcohol Clin Exp Res. 2003 May;27(5):868-79. doi: 10.1097/01.ALC.0000065436.24221.63.
5
Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting.γ-氨基丁酸A型（GABA(A)）受体与酒精依赖的关联及基因印记的影响
Am J Med Genet B Neuropsychiatr Genet. 2003 Feb;117B(1):39-45. doi: 10.1002/ajmg.b.10022.
6
A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818.一项针对韩国人群的九个STR基因座FGA、VWA、D3S1358、D18S51、D21S11、D8S1179、D7S820、D13S317和D5S818的研究。
Int J Legal Med. 2000;114(1-2):41-4. doi: 10.1007/s004140000137.
7
Obsessive-compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale.渴求的强迫观念及强迫行为方面：强迫性饮酒量表的编制
Addiction. 2000 Aug;95 Suppl 2:S211-7. doi: 10.1080/09652140050111771.
8
Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence.γ-氨基丁酸A受体β2、γ-氨基丁酸A受体α6、γ-氨基丁酸A受体α1和γ-氨基丁酸A受体γ2受体亚基基因簇在药物反应及酒精依赖发展中的作用。
Neurochem Int. 2000 Nov-Dec;37(5-6):413-23. doi: 10.1016/s0197-0186(00)00054-1.
9
Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population.苏格兰人群中γ-氨基丁酸A受体β2、γ-氨基丁酸A受体α6和γ-氨基丁酸A受体γ2基因簇变异与酒精依赖之间的关联。
Mol Psychiatry. 1999 Nov;4(6):539-44. doi: 10.1038/sj.mp.4000554.
10
Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol.γ-氨基丁酸A型（GABA(A)）受体γ2亚基变体与酒精急性生理依赖性严重程度的遗传关联。
Mamm Genome. 1998 Dec;9(12):975-8. doi: 10.1007/s003359900909.

韩国人群中酒精中毒与5号染色体q33 - 34上GABAA受体基因的基因多态性之间的关联。

Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population.

作者信息

Park Chul-Soo, Park So-Young, Lee Chul-Soon, Sohn Jin-Wook, Hahn Gyu-Hee, Kim Bong-Jo

机构信息

Department of Psychiatry, College of Medicine, Gyeongsang National University, Jinju, Korea.

出版信息

J Korean Med Sci. 2006 Jun;21(3):533-8. doi: 10.3346/jkms.2006.21.3.533.

DOI:10.3346/jkms.2006.21.3.533
PMID:16778401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2729963/
Abstract

Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. We investigated the association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population. The genotype of the GABAA receptor gene polymorphisms were determined by performing polymerase chain reaction genotyping for 172 normal controls and 162 male alcoholics who are hospitalized in alcoholism treatment institute. We found a significant association between the genetic polymorphisms of the GABAA alpha1 and GABAA alpha6 receptor gene and alcoholism. The GG genotype of the GABAA alpha1 receptor gene was associated with the onset age of alcoholism and alcohol withdrawal symptoms, and a high score on the Korean version of the ADS. However, there was no association between the genetic polymorphisms of the GABAA beta2 and gamma2 receptor gene and alcoholisms. Our finding suggest that genetic polymorphisms of the GABAA alpha1 and GABAA alpha6 receptor gene may be associated with the development of alcoholism and that the GG genotype of the GABAA alpha1 receptor gene play an important role in the development of the early onset and the severe type of alcoholism.

摘要

家族、双胞胎和收养研究表明，基因在酒精中毒的发展过程中起着重要作用。我们调查了韩国人群中酒精中毒与5号染色体q33 - 34上GABAA受体基因的基因多态性之间的关联。通过对172名正常对照者和162名在酒精中毒治疗机构住院的男性酒精中毒患者进行聚合酶链反应基因分型，确定了GABAA受体基因多态性的基因型。我们发现GABAAα1和GABAAα6受体基因的基因多态性与酒精中毒之间存在显著关联。GABAAα1受体基因的GG基因型与酒精中毒的发病年龄、戒酒症状以及韩国版酒精依赖量表（ADS）的高分相关。然而，GABAAβ2和γ2受体基因的基因多态性与酒精中毒之间没有关联。我们的研究结果表明，GABAAα1和GABAAα6受体基因的基因多态性可能与酒精中毒的发展有关，并且GABAAα1受体基因的GG基因型在早发性和严重型酒精中毒的发展中起重要作用。