Peschel Andreas, Sahl Hans-Georg
Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, University of Tübingen, 72076 Tübingen, Germany.
Nat Rev Microbiol. 2006 Jul;4(7):529-36. doi: 10.1038/nrmicro1441. Epub 2006 Jun 12.
Endogenous cationic antimicrobial peptides (CAMPs) are among the most ancient and efficient components of host defence. It is somewhat of an enigma that bacteria have not developed highly effective CAMP-resistance mechanisms, such as those that inhibit many therapeutic antibiotics. Here, we propose that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host-pathogen balance that has shaped the existing CAMP repertoire. Elucidating the underlying principles of this process could help in the development of more sustainable antibiotics.
内源性阳离子抗菌肽（CAMP）是宿主防御中最古老且高效的成分之一。细菌尚未发展出像抑制许多治疗性抗生素那样的高效抗CAMP机制，这多少有些令人费解。在此，我们提出CAMP与抗CAMP机制是共同进化的，导致了一种短暂的宿主-病原体平衡，这种平衡塑造了现有的CAMP库。阐明这一过程的潜在原理有助于开发更具可持续性的抗生素。
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