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使用两亲性阳离子香豆素衍生物根除耐甲氧西林金黄色葡萄球菌生物膜

Eradication of MRSA biofilms using amphiphilic cationic coumarin derivatives.

作者信息

Nitschke Samuel O, Awad Muhammed, Elliott Alysha G, Lowe Gabrielle, Leigh Chris, Neubauer Ken, Thomas Nicky, Hickey Shane M, Plush Sally E

机构信息

Clinical and Health Sciences, University of South Australia Adelaide South Australia 5000 Australia

Basil Hetzel Institute for Translational Health Research Woodville South Australia 5011 Australia.

出版信息

RSC Adv. 2025 Jul 18;15(31):25510-25513. doi: 10.1039/d5ra04358a. eCollection 2025 Jul 15.

DOI:10.1039/d5ra04358a
PMID:40686635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12272568/
Abstract

Amphiphilic coumarin derivatives have demonstrated potent antibiofilm activity against established methicillin-resistant (MRSA) biofilms. Scanning electron microscopy (SEM) revealed morphological changes to bacterial cells and eradication of extracellular matrix from established MRSA biofilms when treated with 7-benzyloxy coumarin derivatives.

摘要

两亲性香豆素衍生物已显示出对已形成的耐甲氧西林金黄色葡萄球菌（MRSA）生物膜具有强大的抗生物膜活性。扫描电子显微镜（SEM）显示，用7-苄氧基香豆素衍生物处理时，已形成的MRSA生物膜中的细菌细胞形态发生变化，细胞外基质被清除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/881e8db90db0/d5ra04358a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/36e5561fe393/d5ra04358a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/f52087c3306f/d5ra04358a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/881e8db90db0/d5ra04358a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/36e5561fe393/d5ra04358a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/f52087c3306f/d5ra04358a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/12272568/881e8db90db0/d5ra04358a-f3.jpg

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本文引用的文献

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RSC Med Chem. 2024 Oct 22. doi: 10.1039/d4md00721b.
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Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria.双胍-万古霉素缀合物是针对活跃生长和生物膜相关革兰氏阳性和革兰氏阴性 ESKAPE 病原体及分枝杆菌的有效广谱抗生素。
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Antimicrobial peptides: Structure, mechanism, and modification.
抗菌肽：结构、作用机制及修饰
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Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance.小分子抗菌肽模拟物作为一种有前途的治疗方法来对抗细菌耐药性。
J Med Chem. 2023 Feb 23;66(4):2211-2234. doi: 10.1021/acs.jmedchem.2c00757. Epub 2023 Feb 5.
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Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents.基于三嗪-哌嗪-三嗪骨架的阳离子两亲性小分子作为一类新型抗菌剂。
Eur J Med Chem. 2022 Dec 5;243:114747. doi: 10.1016/j.ejmech.2022.114747. Epub 2022 Sep 8.
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Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014-2022.近年来半合成糖肽类抗生素的研究进展：2014-2022 年。
ACS Infect Dis. 2022 Aug 12;8(8):1381-1407. doi: 10.1021/acsinfecdis.2c00253. Epub 2022 Jul 27.
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Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery.香豆素类似物作为抗菌剂的分子见解：药物发现的最新进展
Antibiotics (Basel). 2022 Apr 24;11(5):566. doi: 10.3390/antibiotics11050566.
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Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies.聚合物作为用于直接治疗和联合治疗的先进抗菌和抗生物膜剂。
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Tolerance and resistance of microbial biofilms.微生物生物膜的耐受性和抗药性。
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