Zimnyakov Dmitry A, Sviridov Alexander P, Kuznetsova Liana V, Baranov Stepan A, Ignatieva Natali Yu
Department of Optics, Saratov State University, Russia.
Appl Opt. 2006 Jun 20;45(18):4480-90. doi: 10.1364/ao.45.004480.
Speckle-contrast monitoring of laser-mediated tissue modification is examined for the specific case of delivery of speckle-modulated light from the tissue to detector (CCD camera) with a fiber-optic element (bundle). The influence of the transfer properties of a bundle-based optical system on the decorrelation rate of detected dynamic speckles is analyzed. Compared with the widely used method on the base of speckle-contrast analysis in the image plane, the considered technique is characterized by a more pronounced correlation between variations of the contrast of time-averaged speckle patterns and changes in the temperature of the modified tissue. The possibility of characterization of the modification kinetics (in particular, by the evaluation of the characteristic activation energy) using the developed speckle technique is demonstrated.
针对通过光纤元件（光纤束）将散斑调制光从组织传输到探测器（电荷耦合器件相机）的特定情况，研究了激光介导组织改性的散斑对比度监测。分析了基于光纤束的光学系统的传输特性对检测到的动态散斑去相关速率的影响。与图像平面中基于散斑对比度分析的广泛使用的方法相比，所考虑的技术的特点是，时间平均散斑图案对比度的变化与改性组织温度的变化之间具有更明显的相关性。证明了使用所开发的散斑技术表征改性动力学（特别是通过评估特征活化能）的可能性。
