Shifman Mark A, Sun Kexin, Colangelo Christopher M, Cheung Kei-Hoi, Miller Perry, Williams Kenneth
Center for Medical Informatics, Yale University, New Haven, CT, USA.
AMIA Annu Symp Proc. 2005;2005:1111.
We have developed the Yale Protein Expression Database (YPED) to address the storage, retrieval, and integrated analysis of proteomics data generated by Yale's Keck Protein Chemistry and Mass Spectrometry Facility. YPED is Web-accessible and currently handles sample requisition, result reporting and sample comparison for ICAT, DIGE and MUDPIT samples. Sample descriptions are compatible with the evolving MIAPE standards. Peptides and proteins identified using Sequest or Mascot are validated with the Trans-Proteomic Pipeline developed at the Institute of Systems Biology and data from the resulting XML file are stored in the database. Researchers can view, subset and download their data through a secure Web interface.
我们开发了耶鲁蛋白质表达数据库（YPED），以处理由耶鲁大学凯克蛋白质化学与质谱分析设施生成的蛋白质组学数据的存储、检索和综合分析。YPED可通过网络访问，目前可处理ICAT、DIGE和MUDPIT样本的样本申请、结果报告及样本比较。样本描述与不断发展的MIAPE标准兼容。使用Sequest或Mascot鉴定出的肽段和蛋白质，通过系统生物学研究所开发的跨蛋白质组学管道进行验证，所得XML文件中的数据则存储在数据库中。研究人员可通过安全的网络界面查看、筛选和下载他们的数据。
