Hébert Eric
Vectorologie et trafic Intracellulaire, Centre de Biophysique Moléculaire, UPR no 4301 du CNRS, Rue Charles Sadron, 45071 Orleans Cedex 2, France.
Biosci Rep. 2006 Feb;26(1):7-17. doi: 10.1007/s10540-006-9002-3.
The mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR) is a multi-functional transmembrane glycoprotein whose major function is to bind and transport M6P-bearing glycoproteins from the trans-Golgi network or the cell surface to lysosomes. The cell surface M6P/IGF-IIR also bind and internalizes the insulin-like growth factor II. The receptor gene is considered a "candidate" tumor suppressor gene. The phenotypic consequences of loss of M6P/IGF-IIR through somatic mutation are potentially very complex since M6P/IGF-IIR has a number of roles in cellular physiology. Loss of function mutations in M6P/IGF-IIR gene could contribute to multi-step carcinogenesis. In the light of the multi-functional cellular potential roles of the M6P/IGF-IIR the purpose of this review is to highlight some recent data concerning its normal functions and the potential role of its loss in tumor pathophysiology with the aim to try to clarify the possible underlying mechanisms of its involvement in tumor development.
甘露糖-6-磷酸/胰岛素样生长因子II受体（M6P/IGF-IIR）是一种多功能跨膜糖蛋白，其主要功能是结合并将携带M6P的糖蛋白从反式高尔基体网络或细胞表面转运至溶酶体。细胞表面的M6P/IGF-IIR还能结合并内化胰岛素样生长因子II。该受体基因被认为是一个“候选”肿瘤抑制基因。由于M6P/IGF-IIR在细胞生理学中具有多种作用，通过体细胞突变导致M6P/IGF-IIR缺失的表型后果可能非常复杂。M6P/IGF-IIR基因的功能丧失突变可能促成多步骤致癌过程。鉴于M6P/IGF-IIR在细胞中的多种潜在功能，本综述旨在强调一些有关其正常功能以及其缺失在肿瘤病理生理学中的潜在作用的最新数据，以期阐明其参与肿瘤发展的可能潜在机制。
