Division of Molecular Medicine, Rudjer Bosković Institute, Zagreb, Croatia.
Cancer Lett. 2010 Mar 1;289(1):11-22. doi: 10.1016/j.canlet.2009.06.036. Epub 2009 Jul 30.
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.
阳离子非依赖型甘露糖-6-磷酸/胰岛素样生长因子 2 受体（M6P/IGF2R）是一种多功能受体。它参与了多种细胞过程，这些过程在癌症中失调。它的肿瘤抑制作用很久以前就被认识到了。然而，由于其多功能性，要了解它与正常细胞生理学的相关性程度并不容易。因此，更难理解它在致癌作用中的作用。这篇综述介绍了在超过 25 年的癌症研究中获得的与 M6P/IGF2R 相关的关键和重点数据。
