Doyle Sean, Corcoran Amanda
Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland, Maynooth, County Kildare, Ireland.
J Infect Dis. 2006 Jul 15;194(2):154-8. doi: 10.1086/505226. Epub 2006 Jun 9.
Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA (1.6 x 10(8) IU/mL), increase from 19-39 IU/mL to 50-100 IU/mL. We found that, in the presence of 1.6-2.2 x 10(8) IU of B19 DNA/mL in B19-seronegative recipients, a pooled-plasma B19 IgG level of 59.5 IU/mL is insufficient to prevent B19 transmission and subsequent seroconversion. These data should lead to improvements in the assessment of blood-product safety.
关于输注受污染血液制品后对细小病毒B19的免疫反应，目前所知信息甚少。在本研究中，我们发现B19血清反应阳性受者体内的B19 IgG水平可预防再次感染，并且在输注含有B19 DNA（1.6×10⁸ IU/mL）的混合血浆后，该水平从19 - 39 IU/mL升至50 - 100 IU/mL。我们还发现，在B19血清反应阴性受者中，当混合血浆中B19 DNA含量为1.6 - 2.2×10⁸ IU/mL时，59.5 IU/mL的混合血浆B19 IgG水平不足以预防B19传播及随后的血清转化。这些数据应能改进对血液制品安全性的评估。
