Grzegorzewski W J
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Division of Reproductive Endocrinology and Pathophysiology, Department of Local Physiological Regulations, Tuwima 10, 10-747 Olsztyn, Poland.
Pol J Vet Sci. 2006;9(2):127-33.
This study was designed to establish: a) whether boar pheromones, 5alpha-androstenone and 5alpha-androstenol, may affect the contractile reactivity of superficial veins of the face in prepubertal gilts deprived of ovarian hormones, and b) what is the influence of ovarian hormones secreted during sexual maturation on the contractility of these veins. The isolated rings of frontal, facial and dorsal nasal veins were treated with androstenone (5alpha-androst-16-en-3-one), androstenol (5alpha-androst-16-en-3-ol) and testosterone (17beta-hydroxy-4-androsten-3-one) in concentrations of either 1 or 10 microM. Changes in the contractile activity of the isolated vein segments were measured using isometric transducer and recorded on HSE-ACAD W software. Sex boar pheromones androstenol and androstenone affected the contractility of the superficial veins of the face and nose in both of the prepubertal ovariectomized gilts and prepubertal intact animals. The way these veins reacted to pheromones differed between animal groups, particular vessels and even their parts and was also dose - dependent. In prepubertal ovariectomized gilts, androstenol had stronger action and caused the constriction of the facial vein, dorsal nasal vein and the distal part of the frontal vein. Androstenone produced constriction of the nasal vein, distal part of the frontal vein and proximal part of facial vein, but relaxation of the proximal part of the frontal vein and the distal part of the facial vein. In prepubertal untreated gilts, androstenone was more effective and strongly influence on the constricted of the frontal vein and facial vein and produced the relaxation of the nasal vein. Androstenol influence on the constriction the frontal vein and the distal parts of the facial vein and nasal vein, and influence o the relaxtion their proximal parts. Testosterone used as a control androgen affected both superficial veins of the face veins in a dose-dependent manner, and, at a higher dose, increased the contractility more effectively. Only the nasal vein did not react to this hormone. The present results suggest the existence in prepubertal gilts of frontal and facial veins' specific reactivity which may participate in the regulation of blood flow from the nasal cavity to the perihypophyseal vascular complex and play a role in the humoral pathway for the male pheromone priming functions in the central nervous system. This reactivity was displayed by the vessels in prepubertal gilts without ovarian hormones. The presence of active ovaries in maturing gilts changed the reactivity of these veins to pheromones and testosterone.
a）公猪信息素5α-雄烯酮和5α-雄烯醇是否会影响青春期前切除卵巢的后备母猪面部浅静脉的收缩反应性；b）性成熟期间分泌的卵巢激素对这些静脉收缩性有何影响。将额静脉、面静脉和鼻背静脉的分离环分别用浓度为1或10微摩尔的雄烯酮（5α-雄甾-16-烯-3-酮）、雄烯醇（5α-雄甾-16-烯-3-醇）和睾酮（17β-羟基-4-雄甾-3-酮）进行处理。使用等长换能器测量分离静脉段的收缩活性变化，并记录在HSE - ACAD W软件上。公猪性信息素雄烯醇和雄烯酮对青春期前切除卵巢的后备母猪和青春期前未处理的动物的面部和鼻浅静脉的收缩性均有影响。这些静脉对信息素的反应方式在不同动物组、特定血管甚至其不同部位之间存在差异，并且还具有剂量依赖性。在青春期前切除卵巢的后备母猪中，雄烯醇作用更强，可导致面静脉、鼻背静脉和额静脉远端收缩。雄烯酮可使鼻静脉、额静脉远端和面静脉近端收缩，但使额静脉近端和面静脉远端舒张。在青春期前未处理的后备母猪中，雄烯酮更有效，对额静脉和面静脉的收缩影响较大，使鼻静脉舒张。雄烯醇影响额静脉以及面静脉和鼻静脉远端的收缩，并影响它们近端的舒张。用作对照雄激素的睾酮以剂量依赖性方式影响面部的两条浅静脉，且在较高剂量时更有效地增加收缩性。只有鼻静脉对这种激素无反应。目前的结果表明，青春期前的后备母猪存在额静脉和面静脉的特定反应性，这可能参与调节从鼻腔到垂体周围血管复合体的血流，并在中枢神经系统中雄性信息素启动功能的体液途径中发挥作用。这种反应性在青春期前切除卵巢的后备母猪的血管中表现出来。性成熟的后备母猪中活跃卵巢的存在改变了这些静脉对信息素和睾酮的反应性。
