[对氧磷酶1基因Gln192Arg多态性与阿尔茨海默病]

[Paraoxonase 1 gene Gln192Arg polymorphism in and Alzheimer disease].

作者信息

He Xiao-ming, Zhang Zhen-xin, Zhang Jun-wu, Zhou Yong-tao, Tang Mou-ni, Wu Cheng-bin, Hong Zhen

机构信息

Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Zhonghua Nei Ke Za Zhi. 2006 Apr;45(4):270-3.

PMID:16780669

Abstract

OBJECTIVE

The aim of this study was to evaluate the association of Gln192Arg polymorphism in paraoxonase 1 (PON1) gene with Alzheimer's disease (AD) in Chinese Han population.

METHODS

Gln192Arg polymorphism in PON1 gene was detected with real-time PCR (RT-PCR) technique in 521 patients with AD and 578 healthy controls.

RESULTS

The presence of at least one of PON1 R allele (Q/R or R/R) was lower in AD patients as compared with the controls (82.7% vs 87.4%; chi(2) = 4.68, P = 0.03). PON1 gene R allele frequency was lower in AD patients as compared with the controls (60.7% vs 64.7%; chi(2) = 3.85, P = 0.05). One-Way ANOVA showed that PON1 genotype had no effect on the age of onset of AD. Logistic regression analysis demonstrated that the age and sex-adjusted OR for the risk of AD in PON1 R allele carriers was 0.71 (P = 0.044, 95% CI = 0.51 - 0.99).

CONCLUSION

Our results indicate that Gln192Arg polymorphism in PON1 gene is associated with AD and PON1 R allele might be a protective factor for AD in Chinese Han population.

摘要

目的

本研究旨在评估对氧磷酶1（PON1）基因Gln192Arg多态性与中国汉族人群阿尔茨海默病（AD）的相关性。

方法

采用实时荧光定量聚合酶链反应（RT-PCR）技术检测521例AD患者和578例健康对照者的PON1基因Gln192Arg多态性。

结果

与对照组相比，AD患者中至少存在一个PON1 R等位基因（Q/R或R/R）的比例较低（82.7%对87.4%；χ² = 4.68，P = 0.03）。与对照组相比，AD患者的PON1基因R等位基因频率较低（60.7%对64.7%；χ² = 3.85，P = 0.05）。单因素方差分析显示，PON1基因型对AD的发病年龄无影响。逻辑回归分析表明，PON1 R等位基因携带者患AD风险的年龄和性别校正比值比为0.71（P = 0.044，95%可信区间 = 0.51 - 0.99）。