MHC I类分子的下调是乳头瘤病毒E5蛋白共有的特性。
Down-regulation of MHC class I is a property common to papillomavirus E5 proteins.
作者信息
Ashrafi G H, Brown D R, Fife K H, Campo M S
机构信息
Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH, Scotland, UK.
出版信息
Virus Res. 2006 Sep;120(1-2):208-11. doi: 10.1016/j.virusres.2006.02.005. Epub 2006 Jun 15.
The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear. We have reported that the E5 proteins of BPV-1, BPV-4, HPV-16 and HPV-6 down-regulate MHC class I, potentially helping the virus evade the host immune response. Others have described MHC class I down-regulation by HPV-2 E5. We report here that another E5 protein, HPV-83 E5, likewise down-regulates MHC class I and propose that interference with expression, assembly and/or transport of MHC class I is a common property of all E5 proteins evolved by the virus to circumvent host immunosurveillance and thus establish productive infection.
乳头瘤病毒的E5蛋白家族由与细胞内膜区室相关的小疏水蛋白组成。E5蛋白的功能，尤其是人乳头瘤病毒（HPV）的E5蛋白功能，仍远未明确。我们曾报道，牛乳头瘤病毒1型（BPV-1）、牛乳头瘤病毒4型（BPV-4）、人乳头瘤病毒16型（HPV-16）和人乳头瘤病毒6型（HPV-6）的E5蛋白会下调I类主要组织相容性复合体（MHC），这可能有助于病毒逃避宿主免疫反应。其他人也曾描述过人乳头瘤病毒2型（HPV-2）E5蛋白对I类MHC的下调作用。我们在此报告，另一种E5蛋白，即人乳头瘤病毒83型（HPV-83）E5蛋白，同样会下调I类MHC，并提出干扰I类MHC的表达、组装和/或运输是该病毒进化出的所有E5蛋白的共同特性，以规避宿主免疫监视从而建立有效的感染。
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