Féasson L, Camdessanché J-P, El Mandhi L, Calmels P, Millet G-Y
Unité de Recherche PPEH-EA 3062, Faculté de Médecine Jacques-Lisfranc, Université Jean-Monnet, Saint-Etienne, France.
Ann Readapt Med Phys. 2006 Jul;49(6):289-300, 375-84. doi: 10.1016/j.annrmp.2006.04.015. Epub 2006 Apr 25.
To identify the role of fatigue, its evaluation and its causes in the pathophysiology context of acquired or hereditary neuromuscular diseases of the spinal anterior horn cell, peripheral nerve, neuromuscular junction and muscle.
A literature review has been done on Medline with the following keywords: neuromuscular disease, peripheral neuropathy, myopathy, fatigue assessment, exercise intolerance, force assessment, fatigue scale and questionnaire, then with the terms: Fatigue Severity Scale, Chalder Fatigue Scale, Fatigue Questionnaire, Piper Fatigue Scale, electromyography and the combination of the word Fatigue with the following terms: Amyotrophic Lateral Sclerosis (ALS), Post-Polio Syndrome (PPS), Guillain-Barre Syndrome, Immune Neuropathy, Charcot-Marie-Tooth Disease, Myasthenia Gravis (MG), Metabolic Myopathy, Mitochondrial Myopathy, Muscular Dystrophy, Facioscapulohumeral Dystrophy, Myotonic Dystrophy.
Fatigue is a symptom very frequently reported by patients. Fatigue is mainly evaluated by strength loss after an exercise, by change in electromyographic activity during a given exercise and by questionnaires that takes into account the subjective (psychological) part of fatigue. Due to the large diversity of motor disorders, there are multiple clinical expressions of fatigue that differ in their presentation, consequences and therapeutic approach.
This review shows that fatigue has to be taken into account in patients with neuromuscular diseases. In this context, pathophysiology of fatigue often implies the motor component but the disease evolution and the physical obligates of daily life also induce an important psychological component.
确定疲劳在脊髓前角细胞、周围神经、神经肌肉接头和肌肉的获得性或遗传性神经肌肉疾病病理生理背景下的作用、评估方法及其成因。
在Medline上进行了文献综述，使用了以下关键词：神经肌肉疾病、周围神经病变、肌病、疲劳评估、运动不耐受、力量评估、疲劳量表和问卷，然后使用了以下术语：疲劳严重程度量表、查尔德疲劳量表、疲劳问卷、派珀疲劳量表、肌电图，以及“疲劳”一词与以下术语的组合：肌萎缩侧索硬化症（ALS）、小儿麻痹后遗症（PPS）、格林-巴利综合征、免疫性神经病变、夏科-马里-图斯病、重症肌无力（MG）、代谢性肌病、线粒体肌病、肌肉萎缩症、面肩肱型肌营养不良症、强直性肌营养不良症。
疲劳是患者经常报告的症状。疲劳主要通过运动后力量丧失、特定运动期间肌电活动变化以及考虑疲劳主观（心理）部分的问卷来评估。由于运动障碍种类繁多，疲劳有多种临床表型，其表现、后果和治疗方法各不相同。
本综述表明，神经肌肉疾病患者必须考虑疲劳问题。在这种情况下，疲劳的病理生理学通常涉及运动成分，但疾病进展和日常生活中的身体需求也会引发重要的心理成分。
