他汀类药物对内皮功能的非脂质效应。
The nonlipid effects of statins on endothelial function.
作者信息
Beckman Joshua A, Creager Mark A
机构信息
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
出版信息
Trends Cardiovasc Med. 2006 Jul;16(5):156-62. doi: 10.1016/j.tcm.2006.03.003.
Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.
羟甲基戊二酰辅酶A还原酶抑制剂或他汀类药物是过去20年中的神奇药物之一。使用这类降血脂药物可降低各种胆固醇水平患者的发病率和死亡率。在血脂变化之前就能看到该药物的有益作用，这表明非脂质机制可能在介导他汀类药物的这些益处中发挥作用。他汀类药物改善血管结局的一个重要非脂质机制是恢复正常的内皮细胞功能。本综述将讨论他汀类药物对内皮细胞功能的非脂质作用，以突出这些药物带来益处的其他途径。
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