用于心血管疾病中内皮功能障碍的核酸递送
Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases.
作者信息
Deshpande Dipti, Janero David R, Segura-Ibarra Victor, Blanco Elvin, Amiji Mansoor M
机构信息
Northeastern University, Boston, Massachusetts.
Houston Methodist Research Institute, Houston, Texas.
出版信息
Methodist Debakey Cardiovasc J. 2016 Sep;12(3):134-140. doi: 10.14797/mdcj-12-3-134.
Abstract
Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.
摘要
内皮功能障碍与多种心血管疾病的病理生理学相关，涉及先天性和获得性免疫机制的组成部分。识别与内皮功能障碍相关的特征模式和靶点有助于开发用于治疗血管疾病的新型纳米治疗平台。本文综述了基于核酸的内皮功能调节以及旨在针对心血管疾病中内皮功能障碍的不同基于核酸的纳米治疗方法。
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