Moorthy S S, Krishna G, Dierdorf S F
Department of Anesthesia, Riley Children's Hospital, Indiana University Medical Center, Indianapolis.
Anesth Analg. 1991 Sep;73(3):275-7. doi: 10.1213/00000539-199109000-00008.
To determine the electromyographic response of patients with cerebral palsy to vecuronium, 10 children (mean age, 6 yr 10 mo) without cerebral palsy and 11 children with cerebral palsy (mean age, 10 yr 3 mo) were studied. All patients were undergoing abdominal or orthopedic surgery and were anesthetized with isoflurane and nitrous oxide. The time from intravenous administration of 0.1 mg/kg of vecuronium to 25% recovery of control twitch height was 43.9 +/- 5.3 and 18.9 +/- 1.7 min (mean +/- SEM) in children without and with cerebral palsy, respectively (P less than 0.01). The authors conclude that patients with cerebral palsy are either resistant to vecuronium or have a rapid clearance as evidenced by the rapid recovery from neuromuscular blockade.
为确定脑瘫患者对维库溴铵的肌电图反应，对10名无脑瘫儿童（平均年龄6岁10个月）和11名脑瘫儿童（平均年龄10岁3个月）进行了研究。所有患者均接受腹部或矫形外科手术，并用异氟烷和氧化亚氮麻醉。无脑瘫儿童和有脑瘫儿童静脉注射0.1mg/kg维库溴铵至对照抽搐高度恢复25%的时间分别为43.9±5.3分钟和18.9±1.7分钟（平均值±标准误）（P<0.01）。作者得出结论，脑瘫患者要么对维库溴铵耐药，要么清除迅速，从神经肌肉阻滞中快速恢复即证明了这一点。
