Kozlov A S, Angulo M C, Audinat E, Charpak S
Institut National de la Santé et de la Recherche Médicale [corrected] U603, Paris, F-75006 [corrected] France.
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10058-63. doi: 10.1073/pnas.0603741103. Epub 2006 Jun 16.
Interaction between astrocytes and neurons enriches the behavior of brain circuits. By releasing glutamate and ATP, astrocytes can directly excite neurons and modulate synaptic transmission. In the rat olfactory bulb, we demonstrate that the release of GABA by astrocytes causes long-lasting and synchronous inhibition of mitral and granule cells. In addition, astrocytes release glutamate, leading to a selective activation of granule-cell NMDA receptors. Thus, by releasing excitatory and inhibitory neurotransmitters, astrocytes exert a complex modulatory control on the olfactory network.
星形胶质细胞与神经元之间的相互作用丰富了脑回路的行为。通过释放谷氨酸和三磷酸腺苷(ATP),星形胶质细胞可以直接兴奋神经元并调节突触传递。在大鼠嗅球中,我们证明星形胶质细胞释放γ-氨基丁酸(GABA)可导致对二尖瓣细胞和颗粒细胞的持久且同步的抑制。此外,星形胶质细胞释放谷氨酸,导致颗粒细胞N-甲基-D-天冬氨酸(NMDA)受体的选择性激活。因此,通过释放兴奋性和抑制性神经递质,星形胶质细胞对嗅觉网络施加复杂的调节控制。