Colpaert F C, Degryse A D, Van Craenendonck H V
Department of Psychopharmacology, Janssen Pharmaceutica, Beerse, Belgium.
Brain Res Bull. 1991 Apr;26(4):627-31. doi: 10.1016/0361-9230(91)90106-t.
The study attempted to verify whether activation of locus coeruleus neurons by alpha 2 antagonists might improve parkinsonian signs. Treatment with the racemic alpha 2 antagonist R 47 243 of a monkey with MPTP-induced parkinsonian signs normalized blink rate, reduced resting tremor, and improved several other parkinsonian signs. In a second experiment, the (-)-isomer R 62 651 produced a gradual change in tremor which was the inverse of the mannner in which tremor had become installed as the result of progression earlier upon the MPTP challenge. It is proposed that further research be conducted to determine whether alpha 2 antagonists may beneficially influence the progression of Parkinson's disease.
该研究试图验证α2拮抗剂激活蓝斑核神经元是否可能改善帕金森病体征。用消旋α2拮抗剂R 47 243治疗一只患有MPTP诱导的帕金森病体征的猴子，可使眨眼频率正常化，减轻静止性震颤，并改善其他一些帕金森病体征。在第二项实验中，(-)-异构体R 62 651使震颤逐渐发生变化，这种变化与MPTP攻击早期进展导致震颤出现的方式相反。建议进行进一步研究，以确定α2拮抗剂是否可能对帕金森病的进展产生有益影响。
