杏仁核脑源性神经营养因子信号传导是记忆巩固所必需的，但不是消退记忆编码所必需的。
Amygdala BDNF signaling is required for consolidation but not encoding of extinction.
作者信息
Chhatwal Jasmeer P, Stanek-Rattiner Lisa, Davis Michael, Ressler Kerry J
机构信息
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA.
出版信息
Nat Neurosci. 2006 Jul;9(7):870-2. doi: 10.1038/nn1718. Epub 2006 Jun 18.
Abstract
Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.
摘要
脑源性神经营养因子（BDNF）通过酪氨酸激酶B受体（TrkB）发挥作用，被认为是学习的关键调节因子。由于目前尚无可用的TrkB选择性拮抗剂，我们使用了一种编码显性负性TrkB（TrkB.t1）的慢病毒，在条件性恐惧消退过程中拮抗BDNF信号传导。虽然感染TrkB.t1的大鼠在训练过程中的消退表现正常，但其消退记忆的保持受损，这表明杏仁核TrkB激活是稳定消退记忆巩固所必需的。
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本文引用的文献
1
BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.脑源性神经营养因子在成体突触可塑性中的作用：突触巩固假说
Prog Neurobiol. 2005 Jun;76(2):99-125. doi: 10.1016/j.pneurobio.2005.06.003.
2
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.认知增强剂作为心理治疗的辅助手段：D-环丝氨酸在恐惧症患者中的应用以促进恐惧消退。
Arch Gen Psychiatry. 2004 Nov;61(11):1136-44. doi: 10.1001/archpsyc.61.11.1136.
3
Facilitation of memory for extinction of drug-induced conditioned reward: role of amygdala and acetylcholine.促进对药物诱导的条件性奖赏消退的记忆：杏仁核与乙酰胆碱的作用
Learn Mem. 2004 Sep-Oct;11(5):641-7. doi: 10.1101/lm.78504.
4
Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning.脑源性神经营养因子和酪氨酸激酶受体B参与杏仁核依赖性恐惧条件反射。
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5
Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies.焦虑的神经回路：来自结构和功能神经影像学研究的证据。
Psychopharmacol Bull. 2003;37(4):8-25.
6
Neurons in medial prefrontal cortex signal memory for fear extinction.内侧前额叶皮质中的神经元发出恐惧消退记忆的信号。
Nature. 2002 Nov 7;420(6911):70-4. doi: 10.1038/nature01138.
7
L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice.L型电压门控钙通道对于小鼠条件性恐惧的消退是必需的，但对于获得或表达则不是必需的。
J Neurosci. 2002 Oct 15;22(20):9113-21. doi: 10.1523/JNEUROSCI.22-20-09113.2002.
8
Regulation of synaptic plasticity genes during consolidation of fear conditioning.恐惧条件反射巩固过程中突触可塑性基因的调控。
J Neurosci. 2002 Sep 15;22(18):7892-902. doi: 10.1523/JNEUROSCI.22-18-07892.2002.
9
The endogenous cannabinoid system controls extinction of aversive memories.内源性大麻素系统控制厌恶记忆的消退。
Nature. 2002 Aug 1;418(6897):530-4. doi: 10.1038/nature00839.
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J Neurosci. 2002 Mar 15;22(6):2343-51. doi: 10.1523/JNEUROSCI.22-06-02343.2002.
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