Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O. Box: 1419815477, Karaj, Iran.
Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Neurochem Res. 2024 Dec;49(12):3226-3243. doi: 10.1007/s11064-024-04242-5. Epub 2024 Sep 16.
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that may develop after experiencing traumatic events. Preclinical studies use various methods to induce PTSD-like models such as fear-conditioning, single-prolonged stress (SPS), restraint stress, and social defeat. Brain-derived neurotrophic factor (BDNF) is a crucial neurotrophin in mood regulation. Evidence shows BDNF changes in different neuropsychiatric disorders particularly PTSD. This review examined BDNF alterations in preclinical rodent models of PTSD where we demonstrated a wide range of paradoxical changes in BDNF. We found that the fear-conditioning model produced the most inconsistent alterations in BDNF, and suggest that conclusions drawn from these changes be approached with caution. We suggest that BDNF maladaptive changes in social defeat and restraint stress models may be related to the duration of stress, while the SPS model appears to have more consistent results. Ultimately, we propose that evaluating BDNF alterations in the process of treating PTSD symptoms may not be a reliable factor.
创伤后应激障碍（PTSD）是一种神经精神疾病，可能在经历创伤事件后发展。临床前研究使用各种方法来诱导 PTSD 样模型，如恐惧条件反射、单一延长应激（SPS）、束缚应激和社会挫败。脑源性神经营养因子（BDNF）是调节情绪的关键神经营养因子。有证据表明 BDNF 在不同的神经精神疾病中发生变化，特别是 PTSD。本综述检查了 PTSD 临床前啮齿动物模型中的 BDNF 改变，我们在这些模型中显示了 BDNF 的广泛的矛盾变化。我们发现，恐惧条件反射模型产生的 BDNF 改变最不一致，并建议对这些变化得出的结论要谨慎。我们认为，社交挫败和束缚应激模型中 BDNF 的适应性改变可能与应激的持续时间有关，而 SPS 模型似乎有更一致的结果。最终，我们提出，在治疗 PTSD 症状的过程中评估 BDNF 的改变可能不是一个可靠的因素。
