Demers Paul A, Davies Hugh W, Friesen Melissa C, Hertzman Clyde, Ostry Aleck, Hershler Ruth, Teschke Kay
School of Occupational and Environmental Hygiene, University of British Columbia, Vancouver, Canada.
Cancer Causes Control. 2006 Aug;17(6):749-58. doi: 10.1007/s10552-006-0007-9.
The objective of this study is to assess the carcinogenicity of pentachlorophenol and tetrachlorophenol using data from the BC sawmill workers cohort study.
The cohort consisted of 27,464 men employed by 14 sawmills for 1 year or more between 1950 and 1995. Fatal (1950-1995) and incident (1969-1995) cancers were identified using national registries. Plant records and systematic interviews with senior employees were used to estimate dermal exposure. Comparisons were made with the general BC population and dose-response relationships were assessed using Poisson regression.
There were 1,495 fatal cancer and 2,571 incident cancers. There were no large or statistically significant excesses of any of the specific cancers were observed compared to the general population. Internal analyses showed strong dose-response relationships for non-Hodgkin's lymphoma, multiple myeloma, and kidney cancer. These relationships were strongest when exposure was restricted to pentachlorophenol. The strength of the dose-response increased when exposure was lagged by 20 years.
Dermal exposure to pentachlorophenol was associated with non-Hodgkin's lymphoma, multiple myeloma, and kidney cancer, but not with other cancers of a priori interest.
本研究的目的是利用不列颠哥伦比亚省锯木厂工人队列研究的数据评估五氯苯酚和四氯苯酚的致癌性。
该队列由1950年至1995年间受雇于14家锯木厂1年或更长时间的27464名男性组成。使用国家登记处确定致命（1950 - 1995年）和新发（1969 - 1995年）癌症病例。利用工厂记录和对高级员工的系统访谈来估计皮肤暴露情况。与不列颠哥伦比亚省普通人群进行比较，并使用泊松回归评估剂量反应关系。
有1495例致命癌症和2571例新发癌症。与普通人群相比，未观察到任何特定癌症有大量或具有统计学意义的超额病例。内部分析显示非霍奇金淋巴瘤、多发性骨髓瘤和肾癌存在较强的剂量反应关系。当暴露仅限于五氯苯酚时，这些关系最为明显。当暴露滞后20年时，剂量反应的强度增加。
皮肤接触五氯苯酚与非霍奇金淋巴瘤、多发性骨髓瘤和肾癌有关，但与其他预先关注的癌症无关。
