Hertzman C, Teschke K, Ostry A, Hershler R, Dimich-Ward H, Kelly S, Spinelli J J, Gallagher R P, McBride M, Marion S A
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada.
Am J Public Health. 1997 Jan;87(1):71-9. doi: 10.2105/ajph.87.1.71.
This study examined the association between exposure to chlorophenates and the risk of soft tissue sarcoma; non-Hodgkin's lymphoma; Hodgkin's disease; and cancers of the lung, nose, and nasopharynx.
A retrospective cohort study was conducted of 26487 workers employed for at least 1 year between 1950 and 1985 in 11 chlorophenate-using and 3 non-using sawmills in British Columbia, Canada. Exposures by job were ascertained with interviews of senior employees.
Probabilistic record linkage to the Canadian Mortality Data Base and the British Columbia Cancer Registry found 4710 deaths between 1950 and 1990, and 1547 incident cases of cancer between 1969 and 1989. None of the cancers of interest had elevated mortality related to chlorophenate exposure. Non-Hodgkin's lymphoma incidence (n = 65) increased with increasing chlorophenate exposure hours, yielding the following standardized incidence ratios: less than 120 hours 0.68; 120 to 1999 hours, 0.59; 2000 to 3999 hours, 1.04; 4000 to 9999 hours, 1.02; and 10000 or more hours, 1.30.
These results are consistent with the borderline positive associations seen in other recently reported studies of chlorophenate-exposed workforces.
本研究调查了接触氯酚盐与软组织肉瘤、非霍奇金淋巴瘤、霍奇金病以及肺癌、鼻癌和鼻咽癌风险之间的关联。
对1950年至1985年期间在加拿大不列颠哥伦比亚省11家使用氯酚盐和3家不使用氯酚盐的锯木厂工作至少1年的26487名工人进行了一项回顾性队列研究。通过对高级员工的访谈确定工作中的接触情况。
与加拿大死亡率数据库和不列颠哥伦比亚癌症登记处的概率记录链接显示，1950年至1990年期间有4710人死亡，1969年至1989年期间有1547例癌症病例。所关注的癌症中，没有一种因接触氯酚盐而导致死亡率升高。非霍奇金淋巴瘤发病率（n = 65）随着氯酚盐接触时间的增加而上升，得出以下标准化发病率比：少于120小时为0.68；120至1999小时为0.59；2000至3999小时为1.04；4000至9999小时为1.02；10000小时及以上为1.30。
这些结果与最近其他关于接触氯酚盐劳动力的研究中观察到的临界阳性关联一致。
