Young R L, Goldzieher J W, Elkind-Hirsch K, Hickox P G, Chakraborty P K
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Int J Fertil. 1991 May-Jun;36(3):167-71.
An attempt was made to assess the potential role for an antiestrogen in the hormone replacement therapy of menopausal women who have a contraindication to estrogen use. Two groups of menopausal or castrate women were given either conjugated equine estrogen or clomiphene citrate in a cyclic manner for 25 days each month for 3 months. The effects were measured after 3 months and compared with baseline values. Clomiphene lowered FSH slightly, but had no effect on subjective vasomotor symptoms. With respect to bone metabolism, it produced no change in plasma parathyroid hormone level, whereas estrogen lowered it; both compound lowered serum calcium but clomiphene had less effect. The hydroxyproline/creatinine ratio was decreased more by clomiphene than by the estrogen. These findings are consistent with a beneficial effect on bone. Clomiphene had no adverse effects on clotting parameters and showed effects similar to those of conjugated equine estrogens on certain measures of lipid metabolism.
对于有雌激素使用禁忌证的绝经后女性，人们尝试评估抗雌激素在激素替代疗法中的潜在作用。两组绝经或去势女性分别接受结合马雌激素或枸橼酸氯米芬治疗，每月以周期方式给药，每次25天，共3个月。3个月后测量效果并与基线值进行比较。氯米芬使促卵泡激素略有降低，但对主观血管舒缩症状无影响。在骨代谢方面，它对血浆甲状旁腺激素水平没有影响，而雌激素则使其降低；两种化合物均降低血清钙，但氯米芬的作用较小。氯米芬比雌激素更能降低羟脯氨酸/肌酐比值。这些发现与对骨骼的有益作用一致。氯米芬对凝血参数没有不良影响，并且在某些脂质代谢指标上显示出与结合马雌激素相似的效果。
