Barnes R B, Roy S, Lobo R A
Obstet Gynecol. 1985 Aug;66(2):216-9.
Thirty-five women who had undergone a natural or surgical menopause were randomized to receive either 0.625 mg of conjugated estrogen to be ingested for 25 days each month or 150 mg of depo-medroxyprogesterone acetate intramuscularly every three months. Plasma lipids were determined before and after one year of therapy. Serum androgens were measured before and after six months of therapy. Conjugated estrogens and depo-medroxyprogesterone acetate had similar effects on plasma lipids. Cholesterol was decreased (P less than .02 for conjugated estrogen therapy and P less than .01 for depo-medroxyprogesterone acetate therapy), as was low-density lipoprotein cholesterol (P less than .02 for conjugated estrogen and P less than .05 for depo-medroxyprogesterone acetate). Conjugated estrogens also significantly increased high-density lipoprotein cholesterol (P less than .02). High-density lipoprotein cholesterol levels were unchanged after depo-medroxyprogesterone acetate therapy. Serum androgens were generally unchanged after depo-medroxyprogesterone acetate or conjugated estrogen therapy. The data from this study suggest that long-term conjugated estrogen and depo-medroxyprogesterone acetate treatment have similar effects on lipid and androgen levels except that high-density lipoprotein cholesterol was not significantly increased by depo-medroxyprogesterone acetate.
35名经历自然绝经或手术绝经的女性被随机分组，分别接受每月服用25天的0.625毫克结合雌激素，或每三个月肌肉注射150毫克醋酸甲羟孕酮。在治疗一年前后测定血脂。在治疗六个月前后测量血清雄激素。结合雌激素和醋酸甲羟孕酮对血脂有相似的作用。胆固醇降低（结合雌激素治疗P<0.02，醋酸甲羟孕酮治疗P<0.01），低密度脂蛋白胆固醇也降低（结合雌激素P<0.02，醋酸甲羟孕酮P<0.05）。结合雌激素还显著增加高密度脂蛋白胆固醇（P<0.02）。醋酸甲羟孕酮治疗后高密度脂蛋白胆固醇水平无变化。醋酸甲羟孕酮或结合雌激素治疗后血清雄激素一般无变化。该研究数据表明，长期使用结合雌激素和醋酸甲羟孕酮治疗对血脂和雄激素水平有相似影响，只是醋酸甲羟孕酮不会显著增加高密度脂蛋白胆固醇。
