中国广州分离的革兰氏阳性临床菌株中1类整合子的隐匿传播。
Unnoticed spread of class 1 integrons in gram-positive clinical strains isolated in Guangzhou, China.
作者信息
Shi Lei, Zheng Meiping, Xiao Zenghuang, Asakura Masahiro, Su Jianyu, Li Lin, Yamasaki Shinji
机构信息
College of Food and Biological Engineering, South China University of Technology.
出版信息
Microbiol Immunol. 2006;50(6):463-7. doi: 10.1111/j.1348-0421.2006.tb03815.x.
A total of 46 gram-positive bacteria isolated from clinical specimens collected in China were subjected to PCR analysis with the intI1-specific primers, and the intI1-positive strains were further analyzed for their resistance gene cassette. All isolates possessed the class 1 integron in their genomes and the array of gene cassettes was dhfrXII-orfF-aadA2, which is very similar to other organisms except in one isolate carrying an additional copy of the class 1 integron containing the aadA2 gene cassette. Altogether, the results indicate that the class 1 integron is widespread in gram-positive clinical strains isolated in Guangzhou, China.
对从中国收集的临床标本中分离出的46株革兰氏阳性菌，使用intI1特异性引物进行PCR分析，并对intI1阳性菌株进一步分析其抗性基因盒。所有分离株的基因组中均含有1类整合子，基因盒阵列是dhfrXII-orfF-aadA2，这与其他菌株非常相似，只是有一株分离株携带了一个额外的含有aadA2基因盒的1类整合子拷贝。总体而言，结果表明1类整合子在中国广州分离的革兰氏阳性临床菌株中广泛存在。
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