Mwamachi D M, Rurangirwa F R, Musoke A J, McGuire T C
Ministry of Livestock Development, Veterinary Laboratory, Kenya.
Acta Trop. 1991 Apr;49(1):27-36. doi: 10.1016/0001-706x(91)90027-h.
The course of infection and the humoral immune response to Trypanosoma congolense clone ILNat 3.1 were studied in test goat kids receiving colostrum from dams immunized with the surface coat of ILNat 3.1 and control kids that received colostrum from nonimmunized dams. At 24-48 h after birth, all test kids had detectable serum antibodies to the trypanosome clone. There was no difference in the prepatent period between the test and control kids following challenge with 10(3) T. congolense ILNat 3.1 trypanosomes 8 days after birth. After the first 7 days of the experimental period, significantly lower parasitemia was recorded in test kids than in control kids. The mean packed red cell volume of test kids was not significantly different from that of control kids 7 days after infection. The test kids gained as much weight as noninfected control kids; both groups gained twice as much weight as infected control kids. Following infection, all kids developed antibodies against the infecting trypanosome clone. Fifteen test kids had titers equal to or greater than 1280 compared to only two control kids. The test kids survived longer after infection compared to control kids. The results suggest that colostrum from does immunized with the surface of a T. congolense clone did not prevent infection, but decreased parasitemia and prolonged survival of kids challenged with the same clone.
在从用刚果锥虫克隆ILNat 3.1表面包被免疫的母羊获得初乳的试验山羊羔以及从未免疫母羊获得初乳的对照山羊羔中，研究了对刚果锥虫克隆ILNat 3.1的感染过程和体液免疫反应。出生后24至48小时，所有试验山羊羔的血清中均可检测到针对该锥虫克隆的抗体。出生8天后用10³个刚果锥虫ILNat 3.1锥虫进行攻击后，试验山羊羔和对照山羊羔的潜伏期没有差异。在实验期的前7天之后，试验山羊羔的虫血症明显低于对照山羊羔。感染7天后，试验山羊羔的平均红细胞压积与对照山羊羔没有显著差异。试验山羊羔的体重增加与未感染的对照山羊羔相同；两组的体重增加量均是感染对照山羊羔的两倍。感染后，所有山羊羔均产生了针对感染锥虫克隆的抗体。15只试验山羊羔的抗体效价等于或高于1280，而对照山羊羔中只有两只。与对照山羊羔相比，试验山羊羔感染后存活时间更长。结果表明，用刚果锥虫克隆表面免疫的母羊的初乳不能预防感染，但可降低虫血症并延长受相同克隆攻击的山羊羔的存活时间。
