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山羊锥虫病中的免疫抑制：急性刚果锥虫感染对炭疽芽孢疫苗抗体反应的影响。

Immunosuppression in caprine trypanosomiasis: effects of acute Trypanosoma congolense infection on antibody response to anthrax spore vaccine.

作者信息

Mwangi D M, Munyua W K, Nyaga P N

机构信息

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nairobi, Kenya.

出版信息

Trop Anim Health Prod. 1990 May;22(2):95-100. doi: 10.1007/BF02239832.

DOI:10.1007/BF02239832
PMID:2115214
Abstract

Trypanosoma congolense infected goats were vaccinated with Bacillus anthracis spore vaccine to determine the effect of such infection on the humoral immune response to the vaccine. The anti-anthrax antibody levels were severely depressed in infected goats. When trypanocidal therapy was administered to T. congolense infected goats 14 days after infection they developed antibody levels against Bacillus anthracis similar to uninfected controls.

摘要

用炭疽芽孢杆菌疫苗对感染刚果锥虫的山羊进行接种，以确定这种感染对疫苗体液免疫反应的影响。感染山羊体内的抗炭疽抗体水平严重降低。在感染刚果锥虫的山羊感染14天后进行杀锥虫治疗，它们产生的抗炭疽芽孢杆菌抗体水平与未感染的对照组相似。

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2
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本文引用的文献

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The effect of Trypanosoma congolense and T vivax infections on the antibody response of cattle to live rinderpest virus vaccine.刚果锥虫和牛双芽巴贝斯虫感染对牛针对牛瘟活病毒疫苗的抗体反应的影响。
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Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence.不同锥虫菌株的内在免疫抑制活性随寄生虫毒力而变化。
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Recovery of an antiviral antibody response following attrition caused by unrelated infection.由无关感染导致的抗体耗损后抗病毒抗体反应的恢复。
PLoS Pathog. 2014 Jan;10(1):e1003843. doi: 10.1371/journal.ppat.1003843. Epub 2014 Jan 2.
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Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses.锥虫病诱导的B细胞凋亡导致保护性抗寄生虫抗体反应丧失，并消除疫苗诱导的记忆反应。
PLoS Pathog. 2008 May 30;4(5):e1000078. doi: 10.1371/journal.ppat.1000078.
牛对非洲锥虫的免疫反应：针对布氏锥虫可变表面糖蛋白的特异性抗体。
Parasite Immunol. 1981 Summer;3(2):97-106. doi: 10.1111/j.1365-3024.1981.tb00388.x.
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Resistance of cattle to tsetse-transmitted challenge with Trypanosoma brucei or Trypanosoma congolense after spontaneous recovery from syringe-passaged infections.牛在从经注射器传代感染中自然恢复后，对布氏锥虫或刚果锥虫经采采蝇传播的攻击的抵抗力。
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Immunosuppression in bovine trypanosomiasis: studies with louping-ill vaccine.牛锥虫病中的免疫抑制：用跳跃病疫苗进行的研究。
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Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment.对双曲钩端螺旋体和流产布鲁氏菌抗体反应的抑制以及贝尼尔治疗后免疫抑制的恢复。
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